FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
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Citation
Zhang, X., Schnorrer, F. (2017). AIDing-targeted protein degradation in Drosophila.  FEBS J. 284(8): 1178--1181.
FlyBase ID
FBrf0235268
Publication Type
Note
Abstract
Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).
PubMed ID
28382696
PubMed Central ID
DOI
10.1111/febs.14054
Related Publication(s)
Research paper

Regulated protein depletion by the auxin-inducible degradation system in Drosophila melanogaster.
Trost et al., 2016, Fly 10(1): 35--46 [FBrf0232704]

Combining the auxin-inducible degradation system with CRISPR/Cas9-based genome editing for the conditional depletion of endogenous Drosophila melanogaster proteins.
Bence et al., 2017, FEBS J. 284(7): 1056--1069 [FBrf0235096]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS J.
    Title
    FEBS Journal
    Publication Year
    2005-
    ISBN/ISSN
    1742-464X
    Data From Reference