UASt regulatory sequences drive expression of a mutated form of Vps35 that carries an amino acid substitution equivalent to L774M in the orthologous human VPS35 gene, a change whose pathogenicity is uncertain (the variant has been found both in sporadic patients with Parkinson's disease, but also in unaffected individuals). (FlyBase curator comment: the mutation in the Vps35 gene is given as L800M in FBrf0229809, however analysis of the release 6.32 annotated gene model indicates the change to be L798M).