FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term second spliceosomal transesterification activity ID (Ontology) GO:0000386 (Gene Ontology)
Definition Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.[ ISBN:0879695897 PubMed:19239890 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 second spliceosomal transesterification activity (all annotations which use CV term, excluding "NOT" statements)       1
     contributes_to | second spliceosomal transesterification activity       1
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  catalytic activity, acting on a nucleic acid
   |__catalytic activity, acting on RNA
       |__second spliceosomal transesterification activity  1 rec.
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Is a catalytic activity, acting on RNA
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Synonyms
  • "3'-splice site cleavage, exon ligation" BROAD
    "lariat formation, 5'-splice site cleavage" RELATED
Secondary IDs
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Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation"