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General Information
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| Term |
transcription coactivator activity |
ID (Ontology) |
GO:0003713 (Gene Ontology) |
| Definition |
A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.[ PubMed:10213677 PubMed:16858867 ] |
| Also Known As |
"transcription co-activator activity" |
| Comment |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_BIOLOGICAL_PROCESS | 1 | | Genes (FBgn) | GO_CELLULAR_COMPONENT | 2 | | Genes (FBgn) | GO_MOLECULAR_FUNCTION | 93 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Gene Groups | Genes |
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transcription coactivator activity (all annotations which use CV term, excluding "NOT" statements) | 1 | 93 | contributes_to | transcription coactivator activity | -- | 7 | enables | transcription coactivator activity | -- | 86 |
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Relationships
