FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term carbamoyl-phosphate synthase (ammonia) activity ID (Ontology) GO:0004087 (Gene Ontology)
Definition Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate.[ EC:6 ]
Also Known As "carbamoyl phosphate synthase (ammonia) activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 carbamoyl-phosphate synthase (ammonia) activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | carbamoyl-phosphate synthase (ammonia) activity       1
Spanning Tree (Parents/Children)
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  ligase activity
   |__ligase activity, forming carbon-nitrogen bonds
       |__carbamoyl-phosphate synthase (ammonia) activity  1 rec.
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Is a ligase activity, forming carbon-nitrogen bonds
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Synonyms
  • "carbamoyl phosphate synthase (ammonia) activity" EXACT
    "carbamoyl-phosphate synthetase (ammonia) activity" RELATED[ EC:6 ]
    "carbamoyl-phosphate synthetase I activity" RELATED[ EC:6 ]
    "carbamoylphosphate synthase (ammonia)" RELATED[ EC:6 ]
    "carbamoylphosphate synthase activity" RELATED[ EC:6 ]
    "carbamoylphosphate synthetase (ammonia) activity" RELATED[ EC:6 ]
    "carbamylphosphate synthetase activity" RELATED[ EC:6 ]
    "carbamylphosphate synthetase I" RELATED[ EC:6 ]
    "carbmoylphosphate synthetase activity" RELATED[ EC:6 ]
    "carbon-dioxide--ammonia ligase activity" RELATED[ EC:6 ]
    "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" RELATED[ EC:6 ]
    "CPS I activity" NARROW[ EC:6 ]
Secondary IDs
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EC:6.3.4.16
KEGG_REACTION:R00149
MetaCyc:RXN-13202
Reactome:R-HSA-70555 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]"
Reactome:R-HSA-9955543 "CPS1 variants don't synthesize carbamoyl phosphate"
RHEA:18029