FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term protein tyrosine phosphatase activity ID (Ontology) GO:0004725 (Gene Ontology)
Definition Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.[ EC:3 ]
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      23
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
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 Gene Groups Genes
 protein tyrosine phosphatase activity (all annotations which use CV term, excluding "NOT" statements)       2     23
     enables | protein tyrosine phosphatase activity       --      23
 NOT | enables | protein tyrosine phosphatase activity       --       7
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phosphatase activity_____________________
catalytic activity, acting on a protein__|
                                         phosphoprotein phosphatase activity
                                          |__protein tyrosine phosphatase activity  30 rec.
                                              |__MAP kinase tyrosine phosphatase activity 2 rec.
                                              |__non-membrane spanning protein tyrosine phosphatase activity 9 rec.
                                              |__protein tyrosine phosphatase activity, metal-dependent 2 rec.
                                              |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
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Is a phosphoprotein phosphatase activity
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Synonyms
  • "[phosphotyrosine]protein phosphatase activity" RELATED[ EC:3 ]
    "phosphoprotein phosphatase (phosphotyrosine) activity" RELATED[ EC:3 ]
    "phosphotyrosine histone phosphatase activity" RELATED[ EC:3 ]
    "phosphotyrosine phosphatase activity" RELATED[ EC:3 ]
    "phosphotyrosine protein phosphatase activity" RELATED[ EC:3 ]
    "phosphotyrosylprotein phosphatase activity" RELATED[ EC:3 ]
    "PPT-phosphatase activity" RELATED[ EC:3 ]
    "protein phosphotyrosine phosphatase activity" RELATED[ EC:3 ]
    "protein-tyrosine-phosphatase activity" RELATED[ EC:3 ]
    "protein-tyrosine-phosphate phosphohydrolase activity" RELATED[ EC:3 ]
    "PTP-phosphatase activity" RELATED[ EC:3 ]
    "PTPase activity" RELATED[ EC:3 ]
    "tyrosine O-phosphate phosphatase activity" RELATED[ EC:3 ]
    "tyrosylprotein phosphatase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.3.48
MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2"
Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR"
Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2"
Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2"
Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45"
Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)"
Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1"
Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases"
Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn"
Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)"
Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX"
Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET"
Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET"
Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation"
Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2"
Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1"
Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs"
Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6"
Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22"
Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70"
Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248"
Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1172 (Y1148)"
Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021"
Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248"
Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15"
Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12"
Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1"
Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB"
Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3"
Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A"
Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B"
Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS"
Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3"
Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers"
Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3"
Reactome:R-HSA-9865167 "PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)"
Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2"
Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B"
Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1"
Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"
RHEA:10684