FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

TIR domain binding

ID (Ontology)

GO:0070976 (Gene Ontology)

Definition

Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.

Also Known As

"Toll-Interleukin receptor domain binding"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
TIR domain binding (all annotations which use CV term, excluding "NOT" statements)
enables \| TIR domain binding

Spanning Tree (Parents/Children)

  protein binding
   |__protein domain specific binding
       |__TIR domain binding  2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein domain specific binding
Part of
Synonyms & Secondary IDs
Synonyms
	"Toll-Interleukin receptor domain binding" EXACT
Secondary IDs

External Crossreferences & Linkouts