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General Information
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| Term |
systematic evolution of ligands by exponential enrichment |
ID (Ontology) |
MI:0657 (Molecular Interactions) |
| Definition |
RNA and cDNA constructs with variable central sequences and a constant flanking region are collected in a complex library. The library is then screened to select either specific binding partners of a bait molecule (generally a protein) or particular enzymatic activities of the nucleic acid molecules themselves. The selected nucleic acids are amplified using the constant flanking regions to increase their abundance. Cycles of selection-amplification can be repeated to increase the specificity of the targets that, at the end, are individually identified by sequencing.[ PubMed:11539574 ] |
| Also Known As |
"in vitro evolution of nucleic acids" ; "selex" |
| Comment |
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Links to External Ontologies
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Interaction Groups |
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systematic evolution of ligands by exponential enrichment (all annotations which use CV term, excluding "NOT" statements) | 21 |
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Relationships