FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

systematic evolution of ligands by exponential enrichment

ID (Ontology)

MI:0657 (Molecular Interactions)

Definition

RNA and cDNA constructs with variable central sequences and a constant flanking region are collected in a complex library. The library is then screened to select either specific binding partners of a bait molecule (generally a protein) or particular enzymatic activities of the nucleic acid molecules themselves. The selected nucleic acids are amplified using the constant flanking regions to increase their abundance. Cycles of selection-amplification can be repeated to increase the specificity of the targets that, at the end, are individually identified by sequencing.[ PubMed:11539574 ]

Also Known As

"in vitro evolution of nucleic acids" ; "selex"

Comment

Links to External Ontologies

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Interaction Groups
systematic evolution of ligands by exponential enrichment (all annotations which use CV term, excluding "NOT" statements)

Spanning Tree (Parents/Children)

  biochemical
   |__affinity technology
       |__systematic evolution of ligands by exponential enrichment  21 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	affinity technology
Part of
Synonyms & Secondary IDs
Synonyms
	"in vitro evolution of nucleic acids" EXACT PSI-MI-alternate "selex" EXACT PSI-MI-short
Secondary IDs

External Crossreferences & Linkouts