FB2025_01 , released February 20, 2025
Allele: Dmel\cos2
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General Information
Symbol
Dmel\cos2
Species
D. melanogaster
Name
FlyBase ID
FBal0001772
Feature type
allele
Associated gene
Dmel\cos
Associated Insertion(s)
Carried in Construct
Also Known As
cos22, cos2[2]
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Sisson et al., 1997)

loss of function allele

(Liu et al., 2007, Grau and Simpson, 1987)
Mutagen
X ray
(Grau and Simpson, 1987)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Grau and Simpson, 1987)
Description

Deletion of 6.5kb between coordinates +108 and +115, removing the 3' portion of the gene.

(Sisson et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cos2 mutant clones in the wing disc that are derived from the anterior compartment often cross the anterior/posterior compartment boundary.

      (Wang et al., 2000)

      Lethality occurs in the late embryonic and first larval instar stages. The majority of hemizygotes die as larvae. cos2/cos7 and cos6/cos7 flies display local pattern duplications on the anterior margin of the wings and halteres. Mutant embryos derived from germ-line clones show an abnormal deletion-duplication phenotype in each segment, similar to that of ptc mutants. A small part of the denticle belt is absent and the duplication involves quite a large area. The entire belt is composed on average of seven to eight denticle rows. The width of the denticle belts is also reduced. A few embryos show an anterior open phenotype.

      (Grau and Simpson, 1987)

      class I allele cos3 > cos2 > cos1 = cos4 = cos5 > cos6 > cos7

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      cos2 is a suppressor of dorsal thick hair phenotype of Scer\GAL4en-e16E, hhN.UAS

      (Lum, 2003)

      cos2 is a suppressor of embryonic/larval cuticle phenotype of Scer\GAL4en-e16E, hhN.UAS

      (Lum, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of hhN.Scer\UAS under the regulation of Scer\GAL4en-e16E, in cos2 mutants fails to convert tertiary fates (thick, pigmented hair) to ectopic secondary fates (smooth cuticle) on the dorsal epidermis of larvae.

      (Lum, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      cosV5

      (Grau and Simpson, 1987)

      cosV4

      (Grau and Simpson, 1987)

      cosV3

      (Grau and Simpson, 1987)

      cosV2

      (Grau and Simpson, 1987)

      cosV1

      (Grau and Simpson, 1987)
      Fails to complement

      cos7

      (Grau and Simpson, 1987)

      cos6

      (Grau and Simpson, 1987)

      cos5

      (Grau and Simpson, 1987)

      cos4

      (Grau and Simpson, 1987)

      cos3

      (Grau and Simpson, 1987)

      cos1

      (Grau and Simpson, 1987)
      Comments

      The maternal effect is almost completely rescued by cos+ in the zygote. Complements the viable cos alleles, unless flies are simultaneously heterozygous for "Cos" mutants.

      (Grau and Simpson, 1987)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Grau & Simpson.

      Detected in a screen designed to detect mutations lethal when transheterozygous with cosV1, Pka-C1Cos-3.

      (Grau and Simpson, 1987)
      Comments
      Comments

      Allelic series: cos3 >= cos2 >= cos1 = cos4 = cos5 >= cos6 >= cos7.

      (Grau and Simpson, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (15)