A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\cos1

General Information
SymbolDmel\cos1SpeciesD. melanogaster
NameFlyBase IDFBal0001771
Feature typealleleAssociated geneDmel\cos
Also Known Ascos2W1, cos2WI, cos21
Allele classloss of function allele
Mutagenethyl methanesulfonate
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
loss of function allele
(Grau and Simpson, 1987)
Mutagen
ethyl methanesulfonate
(Grau and Simpson, 1987)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal | embryonic stage | rescuable maternal effect
(Grau and Simpson, 1987)
lethal | recessive
(Grau and Simpson, 1987)
hide Phenotype Manifest In
denticle belt | embryonic stage
(Grau and Simpson, 1987)
embryonic/first instar larval cuticle | germline clone
(Grau and Simpson, 1987)
embryonic epidermis | germline clone
(Grau and Simpson, 1987)
embryonic segment | germline clone
(Grau and Simpson, 1987)
follicle cell | ectopic | somatic clone
(Zhang and Kalderon, 2000)
oocyte | somatic clone
(Zhang and Kalderon, 2000)
sex comb | ectopic | somatic clone
(Horabin et al., 2003)
wing
(Sisson et al., 1997)
wing vein
(Sisson et al., 1997)
hide Detailed Description
Statement
Reference
When mutant clones are made in the legs of female adults, slightly thickened bristles are seen, indicating a weak transformation to male.
(Horabin et al., 2003)
Germ cells in the ovary that are homozygous for cos1 develop relatively normally to about stage 6 or 7 and then become necrotic.
(Vied and Horabin, 2001)
Homozygous somatic stem cell clones in the ovary induce cause over-proliferation of follicle cells. In a few egg chambers the oocyte is not at the posterior (less than 1%), but the migration of the oocyte nucleus is always normal.
(Zhang and Kalderon, 2000)
Mutant clones in the wing display extra wing veins and/or mirror image duplications.
(Sisson et al., 1997)
Mutant embryos derived from germ-line clones show very little cuticular differentiation. Those that differentiate cuticle have fewer segments than normal and show an abnormal deletion-duplication phenotype in each segment, similar to that of ptc mutants. Some embryos show an anterior open phenotype. The maternal effect of cos1 is strong, is similar to that caused by "Cos" mutants and is not completely rescued by cos+ in the zygote.
(Grau and Simpson, 1987)
class I allele cos3 > cos2 > cos1 = cos4 = cos5 > cos6 > cos7
 
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hide Phenotype Manifest In
hideSuppressor of
Statement
Reference
cos[+]/cos1 is a suppressor | partially of ovariole phenotype of fu1
(Besse et al., 2002)
cos[+]/cos1 is a suppressor | partially of ovariole phenotype of fu52
(Besse et al., 2002)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Complements
cosV1
(Grau and Simpson, 1987)
cosV2
(Grau and Simpson, 1987)
cosV3
(Grau and Simpson, 1987)
cosV4
(Grau and Simpson, 1987)
cosV5
(Grau and Simpson, 1987)
Fails to complement
cos2
(Grau and Simpson, 1987)
cos3
(Grau and Simpson, 1987)
cos4
(Grau and Simpson, 1987)
cos5
(Grau and Simpson, 1987)
cos6
(Grau and Simpson, 1987)
cos7
(Grau and Simpson, 1987)
cosV1
(Grau and Simpson, 1987)
cosV2
(Grau and Simpson, 1987)
cosV3
(Grau and Simpson, 1987)
cosV4
(Grau and Simpson, 1987)
cosV5
(Grau and Simpson, 1987)
Comments
Complements the viable cos alleles, unless flies are simultaneously heterozygous for "Cos" mutants.
(Grau and Simpson, 1987)
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
Whittle.
R. Whittle.
hide Comments
Allelic series: cos3 >= cos2 >= cos1 = cos4 = cos5 >= cos6 >= cos7.
(Grau and Simpson, 1987)
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym
cos21
(Lefers et al., 2001, Wang and Holmgren, 2000)
cos2W1
(Ho et al., 2005, Lum, 2003, Lum et al., 2003, Vied and Horabin, 2001, Lefers et al., 2001, Zhang and Kalderon, 2000, Wang and Holmgren, 1999, Sisson et al., 1997, Ayers et al., 2009, Zhang et al., 2005)
cos-2W1
(Grau and Simpson, 1987)
cos2WI
(Besse et al., 2002, Sisson et al., 2006, Marks and Kalderon, 2011)
cos1
 
cosw1
(Horabin et al., 2003)
cosWI
(Ruel et al., 2003)
l(2)cos2
(Whittle, 1976)
Name Synonym
Secondary FlyBase IDs
hide References ( 18 )
Research paper
Marks and Kalderon, 2011, Development 138(12): 2533--2542
Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. [FBrf0213757]
Ayers et al., 2009, Dev. Biol. 329(2): 280--293
Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. [FBrf0208057]
Sisson et al., 2006, Dev. Biol. 294(1): 258--270
Regulation of Ci and Su(fu) nuclear import in Drosophila. [FBrf0190163]
Ho et al., 2005, Development 132(6): 1401--1412
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. [FBrf0183921]
Zhang et al., 2005, Dev. Cell 8(2): 267--278
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. [FBrf0183877]
Horabin et al., 2003, Development 130(24): 6101--6109
A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. [FBrf0167511]
Lum et al., 2003, Mol. Cell 12(5): 1261--1274
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. [FBrf0167876]
Ruel et al., 2003, Nat. Cell Biol. 5(10): 907--913
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. [FBrf0167937]
Besse et al., 2002, Development 129(17): 4111--4124
Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation. [FBrf0151279]
Lefers et al., 2001, Dev. Biol. 236(2): 411--420
Genetic dissection of the Drosophila Cubitus interruptus signaling complex. [FBrf0137216]
Vied and Horabin, 2001, Development 128(14): 2649--2660
The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline. [FBrf0138357]
Wang and Holmgren, 2000, Development 127(14): 3131--3139
Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation. [FBrf0128675]
Zhang and Kalderon, 2000, Development 127(10): 2165--2176
Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. [FBrf0127415]
Wang and Holmgren, 1999, Development 126(22): 5097--5106
The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels. [FBrf0112075]
Sisson et al., 1997, Cell 90(2): 235--245
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. [FBrf0096304]
Grau and Simpson, 1987, Dev. Biol. 122: 186--200
The segment polarity gene costal-2 in Drosophila. [FBrf0046012]
Whittle, 1976, Dev. Biol. 51: 257--268
Clonal analysis of a genetically caused duplication of the anterior wing in Drosophila melanogaster. [FBrf0028549]
Supplementary material
Lum, 2003, Molec. Cell 12(5):
[title not yet available] [FBrf0188582]