FlyBase Allele Report: Dmel\cos[1]

General Information

Symbol

Dmel\cos¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001771

Feature type

allele

Associated gene

Dmel\cos

Associated Insertion(s)

Carried in Construct

Also Known As

cos2^W1, cos2^WI, cos2¹

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Grau and Simpson, 1987)

Mutagen

ethyl methanesulfonate

(Grau and Simpson, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | oogenesis | somatic clone

(Zhang and Kalderon, 2000)

increased occurrence of cell division | oogenesis | somatic clone

(Zhang and Kalderon, 2000)

lethal | embryonic stage | rescuable maternal effect

(Grau and Simpson, 1987)

lethal | recessive

(Grau and Simpson, 1987)

Phenotype Manifest In

Detailed Description

Statement

Reference

When mutant clones are made in the legs of female adults, slightly thickened bristles are seen, indicating a weak transformation to male.

(Horabin et al., 2003)

Germ cells in the ovary that are homozygous for cos¹ develop relatively normally to about stage 6 or 7 and then become necrotic.

(Vied and Horabin, 2001)

Homozygous somatic stem cell clones in the ovary induce cause over-proliferation of follicle cells. In a few egg chambers the oocyte is not at the posterior (less than 1%), but the migration of the oocyte nucleus is always normal.

(Zhang and Kalderon, 2000)

Mutant clones in the wing display extra wing veins and/or mirror image duplications.

(Sisson et al., 1997)

Mutant embryos derived from germ-line clones show very little cuticular differentiation. Those that differentiate cuticle have fewer segments than normal and show an abnormal deletion-duplication phenotype in each segment, similar to that of ptc mutants. Some embryos show an anterior open phenotype. The maternal effect of cos¹ is strong, is similar to that caused by "Cos" mutants and is not completely rescued by cos⁺ in the zygote.

(Grau and Simpson, 1987)

class I allele cos³ > cos² > cos¹ = cos⁴ = cos⁵ > cos⁶ > cos⁷

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cos[+]/cos¹ is an enhancer of visible phenotype of Gmap^29B3, Scer\GAL4^sd.PU

(Friggi-Grelin et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

cos[+]/cos¹ is an enhancer of wing phenotype of Gmap^29B3, Scer\GAL4^sd.PU

(Friggi-Grelin et al., 2008)

cos[+]/cos¹ is an enhancer of costal wing cell phenotype of Gmap^29B3, Scer\GAL4^sd.PU

(Friggi-Grelin et al., 2008)

Suppressor of

Statement

Reference

cos[+]/cos¹ is a suppressor of ovariole phenotype of fu¹

(Besse et al., 2002)

cos[+]/cos¹ is a suppressor of ovariole phenotype of fu⁵²

(Besse et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of cos¹ enhances the wing phenotypes seen when Gmap^29B3 is expressed under the control of Scer\GAL4^sd.PU.

(Friggi-Grelin et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

cos^V5

(Grau and Simpson, 1987)

cos^V4

(Grau and Simpson, 1987)

cos^V3

(Grau and Simpson, 1987)

cos^V2

(Grau and Simpson, 1987)

cos^V1

(Grau and Simpson, 1987)

Fails to complement

Comments

Complements the viable cos alleles, unless flies are simultaneously heterozygous for "Cos" mutants.

(Grau and Simpson, 1987)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Whittle.

R. Whittle.

(Grau and Simpson, 1987)

Comments

Allelic series: cos³ >= cos² >= cos¹ = cos⁴ = cos⁵ >= cos⁶ >= cos⁷.

(Grau and Simpson, 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

cos-2^W1

(Grau and Simpson, 1987)

cos2¹

(Lefers et al., 2001, Wang and Holmgren, 2000)

cos2^W1

(Ayers et al., 2009, Ho et al., 2005, Zhang et al., 2005, Lum, 2003, Lum et al., 2003, Lefers et al., 2001, Vied and Horabin, 2001, Zhang and Kalderon, 2000, Wang and Holmgren, 1999, Sisson et al., 1997)

cos2^WI

(Marks and Kalderon, 2011, Sisson et al., 2006, Besse et al., 2002)

cos2^w1

(Friggi-Grelin et al., 2008)

cos¹

cos^WI

(Ruel et al., 2003)

cos^w1

(Horabin et al., 2003)

l(2)cos₂

(Whittle, 1976)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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