Allele Dmel\ctⁿ

General Information
Symbol	Dmel\ctⁿ	Species	D. melanogaster
Name	notch	FlyBase ID	FBal0002094
Feature type	allele	Associated gene	Dmel\ct

Allele class
Mutagen	heat-treatment
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	heat-treatment (Johnson and Judd, 1979, Plough and Ives, 1934)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of roo element. (Georgiev and Gerasimova, 1989) Insertion of roo. (Tchurikov et al., 1989) roo insertion DNA coordinates (FBrf0042060) (0 is gypsy site in ct⁶): -6.8 to -4.8
Caused by insertion	roo{}ctⁿ (Tchurikov et al., 1988, Tchurikov et al., 1989, Georgiev and Gerasimova, 1989)
Cytology	Polytene chromosomes normal. Polytene chromosomes normal. (Johnson and Judd, 1979)
Phenotypic Data
Phenotypic Class
	viable (Johnson and Judd, 1979) visible (Plough and Ives, 1934) visible \| recessive (Jack et al., 1991)
Phenotype Manifest In
	wing (Johnson and Judd, 1979, Jack et al., 1991, Plough and Ives, 1934, de Celis and Bray, 1997)
Detailed Description
	Statement Reference Severe allele that produces extensive loss of wing margin structures. (de Celis and Bray, 1997) Adult wing margin has gaps at the tip. (Jack et al., 1991) Phenotype is unaffected by mod(mdg4)^ul. (Georgiev and Gerasimova, 1989) Notched wings. Completely complemented by Df(1)R19. (Johnson and Judd, 1979) Phenotype is much less extreme than ct¹. Shallow terminal notches are seen between wing veins L2 and L3 and between veins L3 and L4. Some variation in the phenotype is seen. ctⁿ/ct¹ flies have the same phenotype as ctⁿ homozygotes. (Plough and Ives, 1934) cut wings Wings notched at tips. Classification of males reliable, of females harder, but perfect at higher temperatures. Viability excellent. RK1 in male.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference ctⁿ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 4 )
Bloomington	24 ctⁿ oc¹/FM1 3022 ctⁿ otu¹ v²⁴/FM3
Kyoto	105683 ctⁿ oc¹/FM1 106786 ctⁿ otu¹ v²⁴/FM3
Notes on Origin
Discoverer	Ives, 3rd March 1932. Ives

Comments
	Weak ct allele. (Jack et al., 1991) Phenotype showed no interaction with mw². (Rabinow and Birchler, 1990)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	ct^32c3 (Plough and Ives, 1934) ctⁿ (Brandt and Corces, 2008)
Name Synonym	notch
Secondary FlyBase IDs

References ( 17 )
Research paper	Brandt and Corces, 2008, Mol. Genet. Genomics 280(5): 385--396 The Lawc protein is required for proper transcription by RNA polymerase II in Drosophila. [FBrf0206854] de Celis and Bray, 1997, Development 124(17): 3241--3251 Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. [FBrf0098380] Ponomarenko et al., 1997, FEBS Lett. 413(1): 7--10 Burdock, a novel retrotransposon in Drosophila melanogaster, integrates into the coding region of the cut locus. [FBrf0098327] Jack et al., 1991, Development 113: 735--747 Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. [FBrf0053813] Rabinow and Birchler, 1990, Genet. Res. (Camb.) 55: 141--151 Interactions among modifiers of retrotransposon-induced alleles of the white locus of Drosophila melanogaster. [FBrf0051869] Rabinow and Birchler, 1990, Genetics 125: 41--50 Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster. [FBrf0051947] Georgiev and Gerasimova, 1989, Mol. Gen. Genet. 220: 121--126 Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster. [FBrf0050555] Tchurikov et al., 1989, Mol. Gen. Genet. 219: 241--248 Mobile elements and transposition events in the cut locus of Drosophila melanogaster. [FBrf0050561] Tchurikov et al., 1988, Lambert, McDonald, Weinstein, 1988: 103--113 Concerted transposition in Drosophila melanogaster. [FBrf0098741] Jack, 1985, Cell 42: 869--876 Molecular organization of the cut locus of Drosophila melanogaster. [FBrf0042060] Johnson and Judd, 1979, Genetics 92: 485--502 Analysis of the cut locus of Drosophila melanogaster. [FBrf0033190] Plough and Ives, 1935, Genetics 20: 42--69 Induction of mutations by high temperature in Drosophila. [FBrf0003118] Plough and Ives, 1934, D. I. S. 1: 31--34 [New mutants report.] [FBrf0063799]
Abstract	Simonova et al., 1998, A. Dros. Res. Conf. 39: 333A Analysis of new trans-regulatory locus in D. melanogaster. [FBrf0101370] Simonova et al., 1997, A. Dros. Res. Conf. 38: 193C lawc^p1 (leg-arista-wing complex) mutation changing the proneural achaete-scute gene expression leads to the ectopic sensory organ formation in Drosophila. [FBrf0092157] Simonova et al., 1997, Doe, Hall, 1997: 193 Analysis of new trans-regulator locus in Drosophila. [FBrf0099523]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\ctn

Allele Dmel\ctⁿ