|Feature type||allele||Associated gene||Dmel\dsx|
|Also Known As||dsxd+r3|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Produces a shortened transcript.
|Caused by aberration|
|Phenotype Manifest In|
dsx mutants appear intersexual externally. Mutant males exhibit a decrease in male-specific serotonergic neurons, while females display ectopic serotonergic neurons. These neurons are differentially patterned depending on the sex of the mutant. In dsx females, a single cluster of three to four serotonergic neurons develops either ventrally or dorsally. In males, both clusters develop but contain 50% fewer neurons than wild-type males.
dsx/dsx mutant gonads are masculinised with respect to hub formation (germline stem cell niche formation).
In the somatic gonad, stage 15 male dsx1/dsx23 mutant embryos are indistinguishable from wild-type males. In contrast, the gonads of stage 15 female dsx1/dsx23 mutant embryos exhibit a completely masculinized phenotype, in which male-specific somatic gonadal precursors are clearly present.
Both the male and female genital primordia develop in XX genital discs.
XY males show courtship sluggishness when compared to wild type siblings. Aging does not improve the courtship performance. Song pulses are similar to those of dsx+ males, though number and duration of song bouts are much reduced. No sine-song bouts whatsoever are generated by dsx mutants. In elicitation and rejection tests, dsx haplo-X mutants demonstrate an attractiveness that cannot be explained by general enfeeblement, such as inability to reject courtship advances.
XX dsx23/Df(3R)dsx15 flies do not show any male-specific courtship when paired with mature virgin females. 100% of XY dsx23/Df(3R)dsx15 flies show male-specific courtship when paired with mature virgin females. XY dsx23/Df(3R)dsx15 flies have a reduced courtship index (compared to control males) when paired with immature male flies. XY dsx23/Df(3R)dsx15 flies have an essentially normal courtship song compared to control XY flies.
Sex specific neuroblasts fail to undergo any postembryonic divisions in male or female larval nervous systems.
Dorsal musculature does not undergo sexual transformation.
Homozygotes are intersexual. Adults have roughened eyes and deformed legs.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 19 )|