FlyBase Allele Report: Dmel\RpL15[3]

General Information

Symbol

Dmel\RpL15³

Species

D. melanogaster

Name

FlyBase ID

FBal0010085

Feature type

allele

Associated gene

Dmel\RpL15

Associated Insertion(s)

Carried in Construct

Also Known As

1-166-37

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Schulze et al., 2005)

Mutagen

ethyl methanesulfonate

(Schulze et al., 2001, Sinclair et al., 2000, Marchant and Holm, 1988)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A. Mutation is in the 5' splicing consensus of the first intron.

(Schulze et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye (with RpL15^PΔ2)

(Schulze et al., 2001)

eye (with RpL15^PΔ8)

(Schulze et al., 2001)

gonad (with RpL15^PΔ2)

(Schulze et al., 2001)

gonad (with RpL15^PΔ8)

(Schulze et al., 2001)

macrochaeta (with RpL15^PΔ2)

(Schulze et al., 2001)

macrochaeta (with RpL15^PΔ8)

(Schulze et al., 2001)

male genitalia (with RpL15^PΔ2)

(Schulze et al., 2001)

male genitalia (with RpL15^PΔ8)

(Schulze et al., 2001)

wing (with RpL15^PΔ2)

(Schulze et al., 2001)

wing (with RpL15^PΔ8)

(Schulze et al., 2001)

wing hair (with RpL15^PΔ2)

(Schulze et al., 2001)

wing hair (with RpL15^PΔ8)

(Schulze et al., 2001)

wing vein (with RpL15^PΔ2)

(Schulze et al., 2001)

wing vein (with RpL15^PΔ8)

(Schulze et al., 2001)

Detailed Description

Statement

Reference

Adult survivors transheterozygotes with RpL15^PΔ2 or RpL15^PΔ8 are sterile with underdeveloped gonads and show reduced body size, small and thin bristles, rough and/or reduced eyes, misrotated genitalia (males) and wing, wing vein and wing hair phenotypes. Reducing the growth temperature to 22^oC (as compared to 25^oC) increases the incidence of survivors. Sex ratios are also skewed in favour of males in the survivors.

(Schulze et al., 2001)

RpL15³/Df(3L)K-2 animals die during the first larval instar. Only RpL15³/RpL15^PΔ8 males eclose.

(Sinclair et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

In(3L)C90/+, RpL15³ has wing margin | posterior | female phenotype, enhanceable by Su(var)205¹

(Schulze et al., 2005)

Other

Statement

Reference

In(3L)C90/+, RpL15³ has wing margin | posterior | female phenotype

(Schulze et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

13% of RpL15³/In(3L)C90 females have a mutant posterior wing margin phenotype. The penetrance of this phenotype is increased to 81% if the females are also carrying Su(var)205¹/+.

(Schulze et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

RpL15^7-1

(Schulze et al., 2001)

RpL15⁷²

(Schulze et al., 2001)

RpL15^8-1

(Schulze et al., 2001)