FlyBase Allele Report: Dmel\opa[7]

General Information

Symbol

Dmel\opa⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0013271

Feature type

allele

Associated gene

Dmel\opa

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Lee et al., 2007)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage (with opa^12.3)

(Lee et al., 2007)

lethal - all die during embryonic stage (with opa^32.3)

(Lee et al., 2007)

lethal - all die during embryonic stage (with opa^M)

(Lee et al., 2007)

lethal - all die during embryonic stage (with opa^Q)

(Lee et al., 2007)

some die during embryonic stage (with opa^12.3)

(Lee et al., 2007)

some die during embryonic stage (with opa^32.3)

(Lee et al., 2007)

some die during embryonic stage (with opa^M)

(Lee et al., 2007)

some die during embryonic stage (with opa^Q)

(Lee et al., 2007)

visible | somatic clone

(Lee et al., 2007)

Phenotype Manifest In

adult head | somatic clone | ventral

(Lee et al., 2007)

antenna | somatic clone

(Lee et al., 2007)

eye | somatic clone

(Lee et al., 2007)

maxillary palp | somatic clone

(Lee et al., 2007)

rostral membrane | somatic clone

(Lee et al., 2007)

vibrissal bristle | somatic clone

(Lee et al., 2007)

Detailed Description

Statement

Reference

opa⁷ clones induced in the ventral portion of the adult head cause defects while clones in the dorsal head do not affect head morphology. The ventral head defects include loss of ventral eye and rostral membrane tissue, bunched vibrissae, missing or misplaced maxillary palps and missing or malformed antennae.

(Lee et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa⁷ has visible phenotype

(Lee et al., 2007)

Phenotype Manifest In

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa⁷ has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has gena phenotype

(Lee et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

In dpp^TgR46.1/+; opa⁷/+ flies the ventral head is disrupted, the eye is round rather than oval, the sensory vibrissae on the ventral side of the eye are bunched, the maxillary palps are missing, reduced or duplicated, and gena tissue appears to be missing.

(Lee et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

opa^M

(Lee et al., 2007)

opa^Q

(Lee et al., 2007)

opa^32.3

(Lee et al., 2007)