FlyBase Allele Report: Dmel\para[lk5]

General Information

Symbol

Dmel\para^lk5

Species

D. melanogaster

Name

FlyBase ID

FBal0013483

Feature type

allele

Associated gene

Dmel\para

Associated Insertion(s)

Carried in Construct

Also Known As

para^1K5

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Stern et al., 1990)

loss of function allele

(Jarecki and Keshishian, 1995, Keshishian et al., 1993)

Mutagen

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Ganetzky, 1984)

Description

Point mutation.

(Stern et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant

(Zlotkin et al., 1999)

lethal (with para⁶⁰)

(Stern et al., 1990)

lethal | recessive

(Park et al., 2002, Stern et al., 1990)

lethal - all die before end of larval stage | recessive

(Jarecki and Keshishian, 1995, Keshishian et al., 1993)

paralytic | heat sensitive

(Fergestad et al., 2010)

paralytic | heat sensitive (with para⁶³)

(Stern et al., 1990)

paralytic | heat sensitive (with para¹⁰³)

(Stern et al., 1990)

paralytic | heat sensitive (with para¹⁴¹)

(Stern et al., 1990)

paralytic | temperature conditional

(Rieder et al., 2013)

partially lethal (with para⁶³)

(Stern et al., 1990)

partially lethal (with para¹⁰³)

(Stern et al., 1990)

partially lethal (with para¹⁴¹)

(Stern et al., 1990)

some die during larval stage | recessive

(Jarecki and Keshishian, 1995, Keshishian et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

No paralysis is seen in para^lk5/+ mutant flies in response to elevated temperatures.

(Islam et al., 2013)

Flies hemi- or homozygous mutant for para^lk5 show a significant ts-paralytic phenotype.

(Rieder et al., 2013)

Mutant flies show an increased tolerance to the paralytic effect of the toxin AaIT compared to wild-type flies.

(Zlotkin et al., 1999)

Embryos raised at 34^oC show an increased frequency of immature filopodial contacts on muscle fibres 6 and 7 ("collateral sprouts") compared to wild-type embryos raised at 34^oC.

(Jarecki and Keshishian, 1995)

Homozygotes die as first instar larvae.

(Keshishian et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

para^lk5 has lethal phenotype, enhanceable by Scer\GAL4^elav-C155/CaMKII^T287D.UAS

(Park et al., 2002)

Suppressed by

Statement

Reference

Csas^MB04236, para^lk5/para[+] has paralytic | adult stage phenotype, suppressible | partially by Dp(1;4)r⁺l

(Islam et al., 2013)

Enhancer of

Statement

Reference

para^lk5/para[+] is an enhancer of paralytic | adult stage phenotype of Csas^MB04236

(Islam et al., 2013)

para^lk5/para[+] is an enhancer of paralytic | heat sensitive phenotype of SiaT^S23

(Repnikova et al., 2010)

NOT Enhancer of

Statement

Reference

para^lk5/para[+] is a non-enhancer of short lived | dominant phenotype of Atpα^DTS2

(Fergestad et al., 2006)

para^lk5/para[+] is a non-enhancer of short lived | dominant phenotype of Atpα^DTS1

(Fergestad et al., 2006)

Other

Statement

Reference

mle^nap-ts1, para^lk5 has lethal | dominant phenotype

(Ganetzky, 1984)

Phenotype Manifest In

Suppressor of

Statement

Reference

para^lk5 is a suppressor of phenotype of Sh¹⁶

(Stern et al., 1990)

para^lk5 is a suppressor of phenotype of Sh²¹

(Stern et al., 1990)

para^lk5 is a suppressor of phenotype of Sh⁵

(Stern et al., 1990)

para^lk5 is a suppressor of phenotype of Sh⁹

(Stern et al., 1990)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of para^lk5 enhances the paralysis phenotype seen in homozygous Csas^MB04236 mutant flies at elevated temperatures. Onset of paralysis occurs earlier than in Csas^MB04236 mutants alone. This enhancement is suppressed in the presence of a para duplication (Dp(1;4)r⁺l).

(Islam et al., 2013)

The severity of the temperature sensitive paralytic phenotype seen in ST6Gal^S23/ST6Gal^S23 flies is enhanced by para^lk5/+; the time for onset of paralysis at 38[o]C is reduced in the double mutant flies compared to the single mutant.

(Repnikova et al., 2010)

para^lk5/+; Atpα^DTS1/+ double mutants have a similar lifespan to Atpα^DTS1/+ single mutants.

(Fergestad et al., 2006)

Expression of CaMKII^{T287D.Scer\UAS} under the control of Scer\GAL4^elav-C155 enhances the lethality of para^lk5.

(Park et al., 2002)

Dominant suppressor of the leg shaking phenotype of Sh¹⁶, Sh²¹, Sh⁹ and Sh⁵.

(Stern et al., 1990)

Lethal over para⁺ in an mle^nap-ts1 background.

(Ganetzky, 1984)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kreber.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

para-lk5

(Zlotkin et al., 1999)

para^1K5

(Reenan and Rogina, 2008)

para^1K

(Reenan and Rogina, 2008)

para^1k5

(Garber et al., 2012)

para^IK5

(Keshishian et al., 1993)

para^LK5

(Islam et al., 2013, Fergestad et al., 2010, Repnikova et al., 2010)

para^Lk5

(Islam et al., 2013)

para^lk5

(Rieder et al., 2013, Park et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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