FlyBase Allele Report: Dmel\Sry-δ[SF1]

General Information

Symbol

Dmel\Sry-δ^SF1

Species

D. melanogaster

Name

FlyBase ID

FBal0016088

Feature type

allele

Associated gene

Dmel\Sry-δ

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Payre et al., 1994, Crozatier et al., 1992)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G751A Amino acid replacement: E251K. Nucleotide substitution: A430G. Amino acid replacement: I144V. The E251K replacement is within the third zinc finger.

(Crozatier et al., 1992)

sequenced by Crozatier et al., 1992

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:30,043,908..30,043,908 [+]

Nucleotide change:

A30043908G

Reported nucleotide change:

A430G

Amino acid change:

I144V | Sry-delta-PA

Reported amino acid change:

I144V

Comment:

From GB:X76235; first of two mutations associated with this allele.

(Crozatier et al., 1992)

point_mutation

3R:30,044,226..30,044,226 [+]

Nucleotide change:

G30044226A

Reported nucleotide change:

G751A

Amino acid change:

E250K | Sry-delta-PA

Reported amino acid change:

E251K

Comment:

From GB:X76235; second of two mutations associated with this allele.

(Crozatier et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ferrer et al., 1994, Payre et al., 1994)

partially lethal

(Crozatier et al., 1992)

Phenotype Manifest In

gonad | male

(Crozatier et al., 1992)

spermatozoon

(Crozatier et al., 1992)

Detailed Description

Statement

Reference

Embryos laid by rare Sry-δ^SF1/Sry-δ^SF2 females show a similar cuticular morphology to that of strong bcd alleles.

(Payre et al., 1994)

Approximately 60-70% of hemizygous embryos survive. Approximately 30% of hemizygous males survive to adulthood. The male gonad is reduced in size and contains very few spermatozoa bundles, although the seminal vesicles and ejaculatory bulb appear normal. Female Sry-δ^SF1/Df(3R)X3F escapers have a reduced life span.

(Crozatier et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sry-δ^SF1 has lethal phenotype, suppressible by Dpse\Sry-delta^tFa

(Ferrer et al., 1994)

Other

Statement

Reference

Dpse\Sry-delta^tFa, Sry-δ^SF1 has viable phenotype

(Ferrer et al., 1994)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sry-delta[+]/Sry-δ^SF1 is a non-suppressor of female germline stem cell phenotype of piwi²

(Smulders-Srinivasan and Lin, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Lethality is completely rescued by one copy of Dpse\Sry-δ^tFa.

(Ferrer et al., 1994)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Introduction of P{sryDB56,ry⁺} causes partial rescue of the mutant phenotype, the labrum is still affected.

(Payre et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sry-δ^SF1

δSF1

(Ferrer et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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