FB2025_01 , released February 20, 2025
Allele: Dmel\NΔECN.hs
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General Information
Symbol
Dmel\NΔECN.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0033861
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{ΔECN}
Key Links
Transgenic product class
inframe_deletion
(Rebay et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Rebay et al., 1993)
Mutagen
in vitro construct
(Eastman et al., 1997, Rebay et al., 1993)
Progenitor genotype
Carried in construct
P{ΔECN}
Cytology
Description

An activated form of N is expressed under the control of a heat shock promoter.

(Eastman et al., 1997)

An Hsp70 promoter driving N cDNA carrying a deletion of the entire extracellular domain.

(Rebay et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      sensory mother cell & dorsal mesothoracic disc

      (Hu et al., 2002)

      wing vein

      (Matsuno et al., 1995)
      Detailed Description
      Statement
      Reference

      NΔECN.hs blocks SOP formation only in wild type but not nct mutant wing discs.

      (Hu et al., 2002)

      Heat shock during the third larval instar or early pupal stages causes rough eyes with fused/missing ommatidia, bristle irregularities, and other disruptions indicative of cell death. Heat pulses in the middle to late third instar larvae also result in extra macrochaetae. Wings show thickened veins.

      (Rebay et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      NΔECN.hs is a suppressor | partially of neurogenic phenotype | maternal effect | embryonic stage phenotype of pcx3

      (Yamakawa et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of NΔECN.hs in pcx3 embryos which lack maternal and zygotic pcx function partially rescues the neurogenic phenotype is 90% of embryos, while the phenotype is not rescued in the remaining 10% of embryos.

      (Yamakawa et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NΔECN.hs
      NΔECN
      (Powell et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)