FlyBase Allele Report: Dmel\Sdc[k10215]

General Information

Symbol

Dmel\Sdc^k10215

Species

D. melanogaster

Name

FlyBase ID

FBal0043489

Feature type

allele

Associated gene

Dmel\Sdc

Associated Insertion(s)

P{lacW}Sdc^k10215

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}Sdc^k10215

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Baron et al., 2009)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sdc^k10215 heterozygotes resist infection with wild-type group B streptococcus.

(Baron et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Sdc[+]/Sdc^k10215 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sdc[+]/Sdc^k10215 is a non-suppressor of larval brain | third instar larval stage phenotype of AdamTS-A^rnwy2/AdamTS-A^rnwy1

(Skeath et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-A^rnwy1/AdamTS-A^rnwy2 mutant third instar larvae is not suppressed by combination with a single copy of Sdc^k10215.

(Skeath et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Sdc¹⁰⁶⁰⁸

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type