FlyBase Allele Report: Dmel\Tig[A1]

General Information

Symbol

Dmel\Tig^A1

Species

D. melanogaster

Name

FlyBase ID

FBal0090530

Feature type

allele

Associated gene

Dmel\Tig

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bunch et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | wandering third instar larval stage (with Df(2L)BSC185)

(Green et al., 2016)

partially lethal - majority die (with Tig^x)

(Bunch et al., 1998)

partially lethal - majority die | recessive

(Bunch et al., 1998)

Phenotype Manifest In

adult abdomen

(Bunch et al., 1998)

air bubble

(Bunch et al., 1998)

larval somatic muscle cell

(Bunch et al., 1998)

pupa

(Bunch et al., 1998)

wing

(Bunch et al., 1998)

Detailed Description

Statement

Reference

Tig^A1/Df(2L)BSC185 transheterozygous wandering third instar larvae move at significantly lower speed in crawling assays, as compared to controls.

Tig^A1 heterozygous wandering third instar larvae do not present significant increases in the number of muscle detachments and in the hemisegmental gap between dorsal oblique muscles 1 and 2, as compared to controls.

(Green et al., 2016)

Semi-lethal in combination with Tig^x. Adult Tig^x/Tig^A1 escapers have elongated, misshapen abdomens and have wing defects. Adult homozygous escapers have wing defects. Homozygous pupae are 16% longer than wild-type pupae. Pupation, defined by the appearance of a gas bubble in the abdomen, occurs, but dispersion of the bubble and head eversion fail to occur in about half the pupae. Muscle contraction waves that pass from the posterior to the anterior are much slower in homozygous third instar larvae than in wild-type larvae. Homozygous larvae have severe muscle defects.

(Bunch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Tig^A1/Tig[+] is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Tig^A1/Tig[+] is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

Tig^A1/Tig[+] is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Tig^A1/Tig[+] is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

pgant3[+]/Pgant3^c01318, Tig^A1 has visible | dominant | cold sensitive phenotype

(Zhang et al., 2008)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Tig^A1/Tig[+] is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Tig^A1/Tig[+] is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

Tig^A1/Tig[+] is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Tig^A1/Tig[+] is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

Tig^A1/Tig[+], fon^Δ24A has somatic muscle cell | wandering third instar larval stage phenotype

(Green et al., 2016)

Tig^A1/Tig[+], fon^Δ24A has muscle cell of dorsal oblique muscle 1 | wandering third instar larval stage phenotype

(Green et al., 2016)

Tig^A1/Tig[+], fon^Δ24A has muscle cell of dorsal oblique muscle 2 | wandering third instar larval stage phenotype

(Green et al., 2016)

pgant3[+]/Pgant3^c01318, Tig^A1 has wing blade | cold sensitive phenotype

(Zhang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

fon^Δ24A, Tig^A1 double heterozygous wandering third instar larvae present significant increases in the number of muscle detachments and in the hemisegmental gap between dorsal oblique muscles 1 and 2, as compared to single heterozygous or wild-type controls.

(Green et al., 2016)

6% of pgant3^c01318/Tig^A1 double heterozygotes show wing blistering at 18[o]C.

(Zhang et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Tig^x

(Bunch et al., 1998)

Rescued by

Tig^A1/Tig^x is rescued by Tig^UAS.cBa/Scer\GAL4^c363

(Bunch et al., 1998)

Partially rescued by

Tig^A1/Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^elav-C155

(Bunch et al., 1998)

Tig^A1/Tig^x is partially rescued by Tig^LGA.UAS/Scer\GAL4^c363

(Bunch et al., 1998)

Tig^A1/Tig^x is partially rescued by Scer\GAL4^elav-C155/Tig^LGA.UAS

(Bunch et al., 1998)

Comments

The semi-lethality seen in combination with Tig^x is rescued by Tig^Scer\UAS.cBa expressed under the control of Scer\GAL4^c363 or Scer\GAL4^elav-C155, and is partially rescued by Tig^LGA.Scer\UAS expressed under the control of Scer\GAL4^c363 or Scer\GAL4^elav-C155.

(Bunch et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8795

w^*; Tig^A1/CyO, P{lacZ.w⁺}276

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tig^A1

(Luedke et al., 2024, Green et al., 2016, Zhang et al., 2008)

tig^A1

(Thuveson et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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