FB2025_01 , released February 20, 2025
Allele: Dmel\fraGA957
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General Information
Symbol
Dmel\fraGA957
Species
D. melanogaster
Name
FlyBase ID
FBal0098245
Feature type
allele
Associated gene
Dmel\fra
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Stage 16-17 fra23H9/fraGA957 embryos have defects in the anterior commissures (5.4% thin, 0.9% absent) and in the posterior commissures (13.5% thin, 6.3% absent).

        (Spitzweck et al., 2010)

        fraGA957 mutants exhibit fragmented commissures and gaps in longitudinal connectives.

        (Al-Anzi and Wyman, 2009)

        Commissures are thin or absent and there are breaks in the longitudinal connectives.

        (Bashaw and Goodman, 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        fraGA957 has abnormal neuroanatomy phenotype, enhanceable by tutl[+]/tutlex383

        (Al-Anzi and Wyman, 2009)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        fraGA957 has symmetrical commissure phenotype, enhanceable by tutl[+]/tutlex383

        (Al-Anzi and Wyman, 2009)

        fraGA957 has larval longitudinal connective phenotype, enhanceable by tutl[+]/tutlex383

        (Al-Anzi and Wyman, 2009)
        NOT Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        A tutlex383 heterozygous background dramatically enhances the fraGA957 mutant phenotype. fraGA957, tutlex383 double mutants typically have only one thin and fragmented commissure along the entire length of the embryo, indicating an extreme reduction in commissure formation and fragmented longitudinal connectives.

        (Al-Anzi and Wyman, 2009)

        Does not affect the phenotype caused by two copies of P{UAS-fra-robo-Myc} expressed under the control of Scer\GAL4elav.PLu.

        (Bashaw and Goodman, 1999)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        fraGA957
        (Spitzweck et al., 2010, Al-Anzi and Wyman, 2009, Bhat et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)