FB2025_01 , released February 20, 2025
Allele: Dmel\Grip84PG66
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General Information
Symbol
Dmel\Grip84PG66
Species
D. melanogaster
Name
FlyBase ID
FBal0131017
Feature type
allele
Associated gene
Dmel\Grip84
Associated Insertion(s)
P{GawB}Grip84PG66
Carried in Construct
Also Known As
PG66
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Colombie et al., 2006)
Mutagen
Delta2-3 transposase
(Bourbon et al., 2002)
Progenitor genotype
Associated Insertion(s)
P{GawB}Grip84PG66
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      chromosome & procephalic neuroblast | third instar larval stage

      (Colombie et al., 2006)
      Detailed Description
      Statement
      Reference

      In Grip84PG66 homozygous late third instar larvae, the mitotic index of larval brain neuroblasts is elevated 4-5 fold over wild-type levels: cells accumulate in pro-metaphase and metaphase; fewer cells are found in anaphase or telophase. More than half these neuroblasts have overcondensed chromosomes and most have disorganised metaphase plates. In addition around 25% of these neuroblasts are polyploid.

      (Colombie et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Grip84PG66 is rescued by Grip84Ubi-p63E.PC

      (Colombie et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Re-mobilisation of the transposon causes the lethality phenotype to be lost.

      (Bourbon et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Grip84PG66
      (Bartoszewski et al., 2022)
      PG66
      (Colombie et al., 2006)
      l(1)tPG66
      (Colombie et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)