FB2025_01 , released February 20, 2025
Allele: Dmel\Sec61αUAS.cKa.Tag:FLAG
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General Information
Symbol
Dmel\Sec61αUAS.cKa.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0152192
Feature type
allele
Associated gene
Dmel\Sec61α
Associated Insertion(s)
Carried in Construct
P{UAS-Sec61α.FLAG}
Key Links
Transgenic product class
wild_type
(Kanuka et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kanuka et al., 2003)
Mutagen
in vitro construct
(Kanuka et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Sec61α.FLAG}
Cytology
Description

UASt drives expression of Sec61α tagged with Tag:FLAG.

(Kanuka et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sec61α
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      autophagic vacuole & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP

      (Arsham and Neufeld, 2009)

      lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP

      (Arsham and Neufeld, 2009)
      Detailed Description
      Statement
      Reference

      Clonal expression of Sec61αScer\UAS.cKa.T:Zzzz\FLAG in fat bodies (generated using Scer\GAL4Act5C.PP) supresses starvation-induced accumulation of lysosomes and results in fewer and smaller Atg8a-containing autophagosomes.

      (Arsham and Neufeld, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and transfected into S2 cells.

      (Kanuka et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sec61αScer\UAS.cKa.T:Zzzz\FLAG
      Sec61αUAS.cKa.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)