FB2025_01 , released February 20, 2025
Allele: Hsap\APPUAS.YFP
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General Information
Symbol
Hsap\APPUAS.YFP
Species
H. sapiens
Name
FlyBase ID
FBal0156390
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-APP.YFP}
Also Known As
APP-YFP, UAS-APP-YFP, UAS-App::YFP
Key Links
Transgenic product class
wild_type
(Gunawardena et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Gunawardena et al., 2003)
Mutagen
in vitro construct
(Gunawardena et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-APP.YFP}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\APP tagged with YFP.

(Gunawardena et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Tagged with
YFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEA
      (Mou et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4elav.PU>Hsap\APPScer\UAS.T:Avic\GFP-YFP vesicles in larval motor axons display movement in both anterograde and retrograde directions.

      (Shaw and Chang, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of sraScer\UAS.T:Ivir\HA1 increases the percentage of anterograde moving vesicles (and increases speed of vesicle movement in both directions) in Scer\GAL4elav.PU>Hsap\APPScer\UAS.T:Avic\GFP-YFP larval motor axons; co-expression of sraJF02557 increases the percentage of stationary vesicles.

      (Shaw and Chang, 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\APPScer\UAS.T:Avic\GFP-YFP
      Hsap\APPUAS.YFP
      Name Synonyms
      Secondary FlyBase IDs
        References (9)