FB2025_01 , released February 20, 2025
Allele: Dmel\Ogg1f01384
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General Information
Symbol
Dmel\Ogg1f01384
Species
D. melanogaster
Name
FlyBase ID
FBal0182431
Feature type
allele
Associated gene
Dmel\Ogg1
Associated Insertion(s)
PBac{WH}Ogg1f01384
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Yasukawa et al., 2015)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Ogg1f01384
Cytology
Description

Insertion integrated 290 bp upstream of the Ogg1 ATG codon. Scer\UAS within the transposon are in the same orientation as the Ogg1 transcription unit, thus allowing Scer\UAS-regulated over-expression.

(Yasukawa et al., 2015)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant (Ogg1f01384) adult flies exhibit hyper-accumulation of 8-oxo-guanines in midgut cells after paraquat feeding. However, the lifespan of these mutant flies in this oxidative stress assay is not decreased and is actually longer than controls.

      Adult flies over-expressing Ogg1 (Scer\GAL4Act5C.PI, Ogg1f01384) exhibit a significant decrease in 8-oxo-guanines in midgut cells after paraquat feeding.

      Scer\GAL4Act5C.PI-mediated expression of Ogg1f01384 results in a significantly longer lifespan than controls, either under normal feeding conditions or when adults are fed paraquat.

      (Yasukawa et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ogg1f01384
      (Yasukawa et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)