Allele Dmel\CRMP^supA4

General Information
Symbol	Dmel\CRMP^supA4	Species	D. melanogaster
Name		FlyBase ID	FBal0195998
Feature type	allele	Associated gene	Dmel\CRMP

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Rawls, 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: A?T. (Rawls, 2006) Amino acid replacement: D430V. (Rawls, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	chemical sensitive (with Df(3R)noi-B) (Rawls, 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference CRMP^supA4/Df(3R)noi-B flies are more sensitive to 5-fluorouracil than control flies. (Rawls, 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference CRMP^supA4 is a suppressor of visible phenotype of b^unspecified, r^Su(b).cSa (Morris et al., )
Other
Statement Reference CRMP^{fs9a.T:Avic\GFP-EGFP}, CRMP^supA4, b^unspecified, r^Su(b).cSa has visible phenotype (Morris et al., ) CRMP^{T:Avic\GFP-EGFP}, CRMP^supA4, b^unspecified, r^Su(b).cSa has visible phenotype (Morris et al., )
Phenotype Manifest In
Suppressor of
Statement Reference CRMP^supA4 is a suppressor of adult cuticle phenotype of b^unspecified, r^Su(b).cSa (Morris et al., )
Other
Statement Reference CRMP^{fs9a.T:Avic\GFP-EGFP}, CRMP^supA4, b^unspecified, r^Su(b).cSa has adult cuticle phenotype (Morris et al., ) CRMP^{T:Avic\GFP-EGFP}, CRMP^supA4, b^unspecified, r^Su(b).cSa has adult cuticle phenotype (Morris et al., )
Additional Comments
Genetic Interactions
Statement Reference CRMP[supA4] disrupts the suppression of the body colour phenotype of b[unspecified] mutants by r[Su(b).cSa]. CRMP[fs9a.T:Avic\GFP-EGFP] fails to support the suppression of the body colour phenotype of b[unspecified], CRMP[supA4]/CRMP[supK1] double mutants by r[Su(b).cSa] resulting in a dark gray cuticle. CRMP[fs9b.T:Avic\GFP-EGFP] supports the suppression of the body colour phenotype of b[unspecified], CRMP[supA4]/CRMP[supK1] double mutants by r[Su(b).cSa] resulting in a brownish cuticle. (Morris et al., )
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	24477 w^; b¹; kni^ri-1 CRMP^supA4 p^p 40956 w^; P{PYD2GFP}1d; kni^ri-1 CRMP^supA4 p^p
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CRMP^supA4 (Rawls, 2006, Morris et al., 2012, Morris et al., )
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Morris et al., 2012, Genetics 191(4): 1227--1238 Divergent Functions Through Alternative Splicing: The Drosophila CRMP Gene in Pyrimidine Metabolism, Brain, and Behavior. [FBrf0219149] Rawls, 2006, Genetics 172(3): 1665--1674 Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism. [FBrf0192211]
Supplementary material	Morris et al., , Genetics 191(4): 2--3 Supporting Information, File S1. [FBrf0219346]

Allele Dmel\CRMPsupA4

Allele Dmel\CRMP^supA4