FlyBase Allele Report: Dmel\CRMP[supA4]

General Information

Symbol

Dmel\CRMP^supA4

Species

D. melanogaster

Name

FlyBase ID

FBal0195998

Feature type

allele

Associated gene

Dmel\CRMP

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rawls, 2006)

Progenitor genotype

Cytology

Description

Nucleotide substitution: A?T.

(Rawls, 2006)

Amino acid replacement: D417V.

(Rawls, 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,577,915..5,577,915 [+]

Nucleotide change:

A5577915T

Reported nucleotide change:

A?T

Amino acid change:

D412V | CRMP-PA; D417V | CRMP-PE

Reported amino acid change:

D417V

Comment:

The reported amino acid change (D417V) is from Figure 6 of FBrf0192211 and does not agree with the D430V location reported in the text.

(Rawls, 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive (with Df(3R)noi-B)

(Rawls, 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

CRMP^supA4/Df(3R)noi-B flies are more sensitive to 5-fluorouracil than control flies.

(Rawls, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CRMP^supA4 is a suppressor of visible phenotype of Adc^unspecified, r^Su(b).cSa

(Morris et al., 2012)

Other

Statement

Reference

Adc^unspecified, CRMP^EGFP, CRMP^supA4, r^Su(b).cSa has visible phenotype

(Morris et al., 2012)

Adc^unspecified, CRMP^fs9a.EGFP, CRMP^supA4, r^Su(b).cSa has visible phenotype

(Morris et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

CRMP^supA4 is a suppressor of adult cuticle phenotype of Adc^unspecified, r^Su(b).cSa

(Morris et al., 2012)

Other

Statement

Reference

Adc^unspecified, CRMP^EGFP, CRMP^supA4, r^Su(b).cSa has adult cuticle phenotype

(Morris et al., 2012)

Adc^unspecified, CRMP^fs9a.EGFP, CRMP^supA4, r^Su(b).cSa has adult cuticle phenotype

(Morris et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

CRMP^supA4 disrupts the suppression of the body colour phenotype of b^unspecified mutants by r^Su(b).cSa.

CRMP^{fs9a.T:Avic\GFP-EGFP} fails to support the suppression of the body colour phenotype of b^unspecified, CRMP^supA4/CRMP^supK1 double mutants by r^Su(b).cSa resulting in a dark gray cuticle.

CRMP^{fs9b.T:Avic\GFP-EGFP} supports the suppression of the body colour phenotype of b^unspecified, CRMP^supA4/CRMP^supK1 double mutants by r^Su(b).cSa resulting in a brownish cuticle.

(Morris et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

40956

w^*; P{PYD2GFP}1d; kni^ri-1 CRMP^supA4 p^p

24477

w^*; Adc^b-1; kni^ri-1 CRMP^supA4 p^p

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CRMP^supA4

(Morris et al., 2012, Morris et al., 2012, Rawls, 2006)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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