FB2025_01 , released February 20, 2025
Allele: Dmel\slprD314Y.UASp
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General Information
Symbol
Dmel\slprD314Y.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0215662
Feature type
allele
Associated gene
Dmel\slpr
Associated Insertion(s)
Carried in Construct
P{UASp-slpr.KD.D314Y}
Key Links
Transgenic product class
dominant_negative_variant
(Polaski et al., 2006)
missense_variant
(Polaski et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Polaski et al., 2006)
missense_variant
(Polaski et al., 2006)
Mutagen
in vitro construct
(Polaski et al., 2006)
Progenitor genotype
Carried in construct
P{UASp-slpr.KD.D314Y}
Cytology
Description

Amino acid replacement: D314Y.

(Polaski et al., 2006)

UASp regulatory sequences drive expression of a dominant negative form of slpr.

(Polaski et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
slpr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of slprD314Y.Scer\UAS.P\T under the control of Scer\GAL4pnr-MD237 results in a cleft notum phenotype.

      (Polaski et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4pnr-MD237, slprD314Y.UASp has visible phenotype, suppressible by pucE69/puc[+]

      (Polaski et al., 2006)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4pnr-MD237, slprD314Y.UASp has mesonotum phenotype, suppressible by pucE69/puc[+]

      (Polaski et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The cleft notum phenotype seen in flies expressing slprD314Y.Scer\UAS.P\T under the control of Scer\GAL4pnr-MD237 is suppressed almost to wild type by pucE69/+.

      (Polaski et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slprD314Y.Scer\UAS.P\T
      slprD314Y.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (1)