FlyBase Allele Report: Dmel\Prosap[KK101537]

General Information

Symbol

Dmel\Prosap^KK101537

Species

D. melanogaster

Name

FlyBase ID

FBal0231331

Feature type

allele

Associated gene

Dmel\Prosap

Associated Insertion(s)

Carried in Construct

P{KK101537}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101537}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101537

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates retinitis pigmentosa

modeled by ninaE^G69D.UAS

(Chow et al., 2016)

exacerbates Vissers-Bodmer syndrome

modeled by Not1^GD4070

(Vissers et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PU

(Iyer et al., 2016)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Iyer et al., 2016)

Detailed Description

Statement

Reference

Expression of Prosap^KK101537 under the control of Scer\GAL4^GMR.PF has no effect on the adult eye morphology.

(Chow et al., 2016)

Expressing Prosap^KK101537 under the control of Scer\GAL4^GMR.PU leads to a rough eye phenotype.

(Iyer et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Prosap^KK101537, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Prosap^KK101537, Scer\GAL4^GMR.PF is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

Prosap^KK101537, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye phenotype characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced further by co-expression of Prosap.

(Chow et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103592

P{KK101537}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Prosap^KK101537

(Singh et al., 2020)

SHANK3^RNAi

(Vissers et al., 2020)

SHANK3^prosap

(Iyer et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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