FlyBase Allele Report: Dmel\Adcy1[KK109441]

General Information

Symbol

Dmel\Adcy1^KK109441

Species

D. melanogaster

Name

FlyBase ID

FBal0236322

Feature type

allele

Associated gene

Dmel\Adcy1

Associated Insertion(s)

Carried in Construct

P{KK109441}

Also Known As

UAS-rut RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109441}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109441

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^C57

(Tsai et al., 2012)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

(Tsai et al., 2012)

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^DBD.Mef2.247

(Widmer et al., 2018)

Phenotype Manifest In

NMJ bouton | larval stage, with Scer\GAL4^C57

(Tsai et al., 2012)

NMJ bouton | larval stage | increased number, with Scer\GAL4^elav.PU

(Tsai et al., 2012)

Detailed Description

Statement

Reference

Expression of rut^KK109441 under the control of Scer\GAL4^da.G32 has no effect on bouton number per muscle area at the larval neuromuscular junction.

Expression of rut^KK109441 under the control of Scer\GAL4^elav.PU results in an increase in bouton number per muscle area at the larval neuromuscular junction.

Expression of rut^KK109441 under the control of Scer\GAL4^C57 results in a decrease in bouton number per muscle area at the larval neuromuscular junction.

(Tsai et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^NP1227/Adcy1^KK109441 is a suppressor of abnormal smell perception phenotype of Ecol\lexA^GAD.GH146, TrpA1^{lexAop.Tag:NLS(SV40-largeT)}

(Sudhakaran et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Ethyl butyrate induced habituation in flies expressing TrpA1^{Ecol\lexAop.T:SV40\nls2} under the control of Ecol\lexA^{GH146.T:Scer\GAL4-GAD} is greatly reduced in the presence of a rut^KK109441 transgene (expressed under the control of Scer\GAL4^NP1227).

(Sudhakaran et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101759

P{KK109441}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Adcy1^KK109441

rut^KK109441

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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