FlyBase Allele Report: Hsap\APP[1-42.UAS]

General Information

Symbol

Hsap\APP^1-42.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0246837

Feature type

allele

Associated gene

Hsap\APP

Associated Insertion(s)

Carried in Construct

P{UAS-Abeta1-42.G}

Also Known As

UAS-AΒ42

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Goldstein, 2010.10.12)

Progenitor genotype

Carried in construct

P{UAS-Abeta1-42.G}

Cytology

Description

UAS regulatory sequences drive expression of the 42 amino acid Abeta42 fragment of Hsap\APP.

(Goldstein, 2010.10.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\APP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Burr et al., 2014)

model of Alzheimer's disease 1

CEA

(Wang and Davis, 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Alzheimer's disease 1

is ameliorated by EDTP^HMS01577

(Xiao et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived, with Scer\GAL4^Toll-6-D42

(Xiao et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsap\APP^{1-42.Scer\UAS} in fly eyes (under the control of Scer\GAL4^GMR.long) causes mild degeneration, although there is no visible disruption of external eye morphology at day 1.

(Burr et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\APP^1-42.UAS, Scer\GAL4^Toll-6-D42 has short lived phenotype, suppressible by EDTP^HMS01577, Scer\GAL4^Toll-6-D42

(Xiao et al., 2019)

Other

Statement

Reference

EDTP^HMS01577, Hsap\APP^1-42.UAS, Scer\GAL4^Toll-6-D42 has long lived phenotype

(Xiao et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32038

P{UAS-Abeta1-42.G}1, w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\APP^{1-42.Scer\UAS}

Hsap\APP^1-42.UAS

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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