Allele Dmel\Liprin-β^Δ51

General Information
Symbol	Dmel\Liprin-β^Δ51	Species	D. melanogaster
Name		FlyBase ID	FBal0248998
Feature type	allele	Associated gene	Dmel\Liprin-β

Allele class	amorphic allele - molecular evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - molecular evidence (Astigarraga et al., 2010)
Mutagen	Delta2-3 (Astigarraga et al., 2010)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}Liprin-β^EY22999 (Astigarraga et al., 2010)
Nature of the lesion	Statement Reference A 1.85kb deletion extending into the Liprin-β gene from the P{EPgy2}Liprin-β[EY22999] insertion site in the 5'UTR. (Astigarraga et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Astigarraga et al., 2010) neuroanatomy defective (with Liprin-β^Δ83) (Astigarraga et al., 2010) partially lethal - majority die \| recessive (Astigarraga et al., 2010)
Phenotype Manifest In
	medulla (Astigarraga et al., 2010) medulla (with Liprin-β^Δ83) (Astigarraga et al., 2010) NMJ bouton \| larval stage (Astigarraga et al., 2010) photoreceptor cell R7 (Astigarraga et al., 2010) photoreceptor cell R7 (with Liprin-β^Δ83) (Astigarraga et al., 2010)
Detailed Description
	Statement Reference 14-17% of R7 axons show projections extending beyond the M6 layer of the medulla in Liprin-β[Δ83]/Liprin-β[Δ51] mutants. R7 axons show projections extending beyond the M6 layer of the medulla. The number of synaptic boutons at the muscle 6/7 synapses in abdominal segments A2 and A3 in Liprin-β[Δ51] animals is ~70% of that from control larvae. Viability is 86% of the expected number. (Astigarraga et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Liprin-β^Δ51 has partially lethal - majority die \| recessive phenotype, enhanceable by Liprin-α^oos (Astigarraga et al., 2010)
Suppressed by
Statement Reference Liprin-β^Δ51 has neuroanatomy defective phenotype, suppressible \| partially by trio^{elav.T:Hsap\MYC} (Astigarraga et al., 2010)
NOT suppressed by
Statement Reference Liprin-β^Δ51 has neuroanatomy defective phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1 (Astigarraga et al., 2010)
Enhancer of
Statement Reference Liprin-β^Δ51 is an enhancer of partially lethal - majority die \| recessive phenotype of Liprin-α^oos (Astigarraga et al., 2010)
Other
Statement Reference Lar^unspecified, Liprin-β^Δ51 has neuroanatomy defective phenotype (Astigarraga et al., 2010) Liprin-α^oos, Liprin-β^Δ51 has neuroanatomy defective phenotype (Astigarraga et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Liprin-β^Δ51 has NMJ bouton \| larval stage phenotype, enhanceable by Liprin-α^oos (Astigarraga et al., 2010)
Suppressed by
Statement Reference Liprin-α^oos, Liprin-β^Δ51 has NMJ bouton \| larval stage phenotype, suppressible \| partially by Liprin-γ^H1/Liprin-γ^S1 (Astigarraga et al., 2010) Liprin-β^Δ51 has medulla phenotype, suppressible \| partially by trio^{elav.T:Hsap\MYC} (Astigarraga et al., 2010) Liprin-β^Δ51 has NMJ bouton \| larval stage phenotype, suppressible by Liprin-γ^H1/Liprin-γ^S1 (Astigarraga et al., 2010) Liprin-β^Δ51 has photoreceptor cell R7 phenotype, suppressible \| partially by trio^{elav.T:Hsap\MYC} (Astigarraga et al., 2010)
NOT suppressed by
Statement Reference Liprin-β^Δ51 has medulla phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1 (Astigarraga et al., 2010) Liprin-β^Δ51 has photoreceptor cell R7 phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1 (Astigarraga et al., 2010)
Enhancer of
Statement Reference Liprin-β^Δ51 is an enhancer of NMJ bouton \| larval stage phenotype of Liprin-α^oos (Astigarraga et al., 2010)
Other
Statement Reference Lar^unspecified, Liprin-β^Δ51 has medulla phenotype (Astigarraga et al., 2010) Lar^unspecified, Liprin-β^Δ51 has photoreceptor cell R7 phenotype (Astigarraga et al., 2010) Liprin-α^oos, Liprin-β^Δ51 has medulla phenotype (Astigarraga et al., 2010) Liprin-α^oos, Liprin-β^Δ51 has photoreceptor cell R7 phenotype (Astigarraga et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference In Liprin-α[oos], Liprin-β[Δ51] double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla. In Lar[unspecified], Liprin-β[Δ51] double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla. Expression of trio[elav.T:Hsap\MYC] rescues the overgrowth of R7 axons in Liprin-β[Δ51] mutants. Liprin-α[oos], Liprin-β[Δ51] double mutants show an additional 25-30% decrease in bouton number compared with either single mutant. The viability of double mutants (4% of the expected number) is reduced compared to either single mutant. Liprin-β[Δ51], Liprin-γ[S1]/Liprin-γ[H1] double mutants form more synaptic boutons than Liprin-β[Δ51] single mutants and resemble controls. Liprin-α[oos], Liprin-β[Δ51], Liprin-γ[S1]/Liprin-γ[H1] triple mutant synapses are larger than Liprin-α[oos], Liprin-β[Δ51] double mutants. (Astigarraga et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Liprin-β^Δ83/Liprin-β^Δ51 is rescued by Scer\GAL4^elav-C155/Liprin-β^{Scer\UAS.T:Ivir\HA1} (Astigarraga et al., 2010)
Partially rescued by	Liprin-β^Δ83/Liprin-β^Δ51 is partially rescued by Scer\GAL4^elav-C155/Liprin-β^{Scer\UAS.T:Ivir\HA1} (Astigarraga et al., 2010)
Comments	Scer\GAL4[elav-C155]-mediated expression of Liprin-β[Scer\UAS.T:Ivir\HA1] significantly rescues the aberrant axon termination phenotype seen in Liprin-β[Δ83]/Liprin-β[Δ51] mutants. Scer\GAL4[elav-C155]-mediated expression of Liprin-β[Scer\UAS.T:Ivir\HA1] restores the number of boutons in Liprin-β[Δ83]/Liprin-β[Δ51] animals to control levels. (Astigarraga et al., 2010)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Liprin-β^Δ51 (Astigarraga et al., 2010) β^Δ51 (Astigarraga et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Astigarraga et al., 2010, J. Neurosci. 30(46): 15358--15368 Three Drosophila liprins interact to control synapse formation. [FBrf0212351]

Allele Dmel\Liprin-βΔ51

Allele Dmel\Liprin-β^Δ51