FlyBase Allele Report: Dmel\Liprin-β[Δ51]

General Information

Symbol

Dmel\Liprin-β^Δ51

Species

D. melanogaster

Name

FlyBase ID

FBal0248998

Feature type

allele

Associated gene

Dmel\Liprin-β

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Astigarraga et al., 2010)

Mutagen

Delta2-3 transposase

(Astigarraga et al., 2010)

Progenitor genotype

P{EPgy2}Liprin-β^EY22999

(Astigarraga et al., 2010)

Cytology

Description

A 1.85kb deletion extending into the Liprin-β gene from the P{EPgy2}Liprin-β^EY22999 insertion site in the 5'UTR.

(Astigarraga et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:13,513,368..13,515,218 [+]

Comment:

Approximate endpoints of deletion of reported length 1.85kb, which extends from P{EPgy2}Liprin-beta^EY22999 into Liprin-beta.

(Astigarraga et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Astigarraga et al., 2010)

abnormal neuroanatomy (with Liprin-β^Δ83)

(Astigarraga et al., 2010)

partially lethal - majority die | recessive

(Astigarraga et al., 2010)

Phenotype Manifest In

medulla

(Astigarraga et al., 2010)

medulla (with Liprin-β^Δ83)

(Astigarraga et al., 2010)

NMJ bouton | larval stage

(Astigarraga et al., 2010)

photoreceptor cell R7

(Astigarraga et al., 2010)

photoreceptor cell R7 (with Liprin-β^Δ83)

(Astigarraga et al., 2010)

Detailed Description

Statement

Reference

14-17% of R7 axons show projections extending beyond the M6 layer of the medulla in Liprin-β^Δ83/Liprin-β^Δ51 mutants.

R7 axons show projections extending beyond the M6 layer of the medulla.

The number of synaptic boutons at the muscle 6/7 synapses in abdominal segments A2 and A3 in Liprin-β^Δ51 animals is ~70% of that from control larvae.

Viability is 86% of the expected number.

(Astigarraga et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Liprin-β^Δ51 has partially lethal - majority die | recessive phenotype, enhanceable by Liprin-α^oos

(Astigarraga et al., 2010)

Suppressed by

Statement

Reference

Liprin-β^Δ51 has abnormal neuroanatomy phenotype, suppressible | partially by trio^elav.Tag:MYC

(Astigarraga et al., 2010)

NOT suppressed by

Statement

Reference

Liprin-β^Δ51 has abnormal neuroanatomy phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Enhancer of

Statement

Reference

Liprin-β^Δ51 is an enhancer of partially lethal - majority die | recessive phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ51 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ51 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Liprin-β^Δ51 has NMJ bouton | larval stage phenotype, enhanceable by Liprin-α^oos

(Astigarraga et al., 2010)

Suppressed by

Statement

Reference

Liprin-α^oos, Liprin-β^Δ51 has NMJ bouton | larval stage phenotype, suppressible | partially by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Liprin-β^Δ51 has photoreceptor cell R7 phenotype, suppressible | partially by trio^elav.Tag:MYC

(Astigarraga et al., 2010)

Liprin-β^Δ51 has medulla phenotype, suppressible | partially by trio^elav.Tag:MYC

(Astigarraga et al., 2010)

Liprin-β^Δ51 has NMJ bouton | larval stage phenotype, suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

NOT suppressed by

Statement

Reference

Liprin-β^Δ51 has photoreceptor cell R7 phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Liprin-β^Δ51 has medulla phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Enhancer of

Statement

Reference

Liprin-β^Δ51 is an enhancer of NMJ bouton | larval stage phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ51 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ51 has medulla phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ51 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ51 has medulla phenotype

(Astigarraga et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

In Liprin-α^oos, Liprin-β^Δ51 double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla.

In Lar^unspecified, Liprin-β^Δ51 double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla.

Expression of trio^{elav.T:Hsap\MYC} rescues the overgrowth of R7 axons in Liprin-β^Δ51 mutants.

Liprin-α^oos, Liprin-β^Δ51 double mutants show an additional 25-30% decrease in bouton number compared with either single mutant. The viability of double mutants (4% of the expected number) is reduced compared to either single mutant.

Liprin-β^Δ51, Liprin-γ^S1/Liprin-γ^H1 double mutants form more synaptic boutons than Liprin-β^Δ51 single mutants and resemble controls.

Liprin-α^oos, Liprin-β^Δ51, Liprin-γ^S1/Liprin-γ^H1 triple mutant synapses are larger than Liprin-α^oos, Liprin-β^Δ51 double mutants.

(Astigarraga et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Liprin-β^Δ83/Liprin-β^Δ51 is rescued by Scer\GAL4^elav-C155/Liprin-β^UAS.Tag:HA

(Astigarraga et al., 2010)

Partially rescued by

Liprin-β^Δ83/Liprin-β^Δ51 is partially rescued by Scer\GAL4^elav-C155/Liprin-β^UAS.Tag:HA

(Astigarraga et al., 2010)

Comments

Scer\GAL4^elav-C155-mediated expression of Liprin-β^{Scer\UAS.T:Ivir\HA1} significantly rescues the aberrant axon termination phenotype seen in Liprin-β^Δ83/Liprin-β^Δ51 mutants.

Scer\GAL4^elav-C155-mediated expression of Liprin-β^{Scer\UAS.T:Ivir\HA1} restores the number of boutons in Liprin-β^Δ83/Liprin-β^Δ51 animals to control levels.

(Astigarraga et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Liprin-β^Δ51

(Astigarraga et al., 2010)

β^Δ51

(Astigarraga et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (1)

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