FB2025_01 , released February 20, 2025
Allele: Dmel\MicalΔPIR.UAS
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General Information
Symbol
Dmel\MicalΔPIR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264694
Feature type
allele
Associated gene
Dmel\Mical
Associated Insertion(s)
Carried in Construct
P{UAS-Mical.ΔPIR}
Key Links
Transgenic product class
inframe_deletion
(Hung et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Hung et al., 2010)
Mutagen
in vitro construct
(Hung et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Mical.ΔPIR}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of the "short" isoform of Mical, in which the plexin-interacting region (PIR) has been removed.

(Hung et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mical
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MicalΔPIR.Scer\UAS under the control of Scer\GAL4B11-98 results in branched bristles.

      Growth cones expressing MicalΔPIR.Scer\UAS under the control of Scer\GAL4eve.RN2 occupy a larger area than control growth cones.

      (Hung et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      MicalΔPIR.UAS, Scer\GAL4B11-98 has visible phenotype, non-suppressible by PlexAunspecified/plexA[+]

      (Hung et al., 2010)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      MicalΔPIR.UAS, Scer\GAL4B11-98 has macrochaeta phenotype, non-suppressible by PlexAunspecified/plexA[+]

      (Hung et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      plexAunspecified/+ does not suppress the branched bristle phenotype caused by expression of MicalΔPIR.Scer\UAS under the control of Scer\GAL4B11-98.

      (Hung et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MicalΔPIR.Scer\UAS
      MicalΔPIR.UAS
      MicalΔPIR
      (Hung et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)