FB2025_01 , released February 20, 2025
Allele: Dmel\tioΔZn4.UAS.cDa
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General Information
Symbol
Dmel\tioΔZn4.UAS.cDa
Species
D. melanogaster
Name
FlyBase ID
FBal0279790
Feature type
allele
Associated gene
Dmel\tio
Associated Insertion(s)
Carried in Construct
PBac{UAS-tio.ΔZn4}
Also Known As
UAS-TioΔZn4
Key Links
Transgenic product class
inframe_deletion
(Datta et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Datta et al., 2011)
Mutagen
in vitro construct
(Datta et al., 2011)
Progenitor genotype
Carried in construct
PBac{UAS-tio.ΔZn4}
Cytology
Description

UAS regulatory sequences drive expression of tio lacking zinc finger 4. Amino acids 1-927 are fused to amino acids 950-1025.

(Datta et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tio
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.cUa
      (Moran et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tioΔZn4.Scer\UAS.cDa under the control of Scer\GAL4dpp.PS induces ectopic eyes in 22% of antennal discs. The ectopic eyes produced are similar in size to those seen when a full length tio construct, tioScer\UAS.cDa, is expressed.

      Antennal disc clones expressing tioΔZn4.Scer\UAS.cDa under the control of Scer\GAL4Scer\FRT.Act5C exhibit tissue overgrowth throughout the disc.

      (Datta et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tioΔZn4.Scer\UAS.cDa
      tioΔZn4.UAS.cDa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)