FlyBase Allele Report: Dmel\Dora[A]

General Information

Symbol

Dmel\Dora^A

Species

D. melanogaster

Name

FlyBase ID

FBal0291273

Feature type

allele

Associated gene

Dmel\Dora

Associated Insertion(s)

Carried in Construct

Also Known As

pldo^A

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Yamamoto et al., 2013-)

Progenitor genotype

Cytology

Description

Amino acid replacement: W946term.

(Yamamoto et al., 2013-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:18,874,432..18,874,432 [+]

Nucleotide change:

G18874432A

Amino acid change:

W946term | Dora-PA; W945term | Dora-PB; W946term | Dora-PC

Reported amino acid change:

W946term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Haelterman et al., 2014, Yamamoto et al., 2013-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dora^A has increased mortality during development phenotype, suppressible | partially by Df(2R)mir-309-6^Δ1

(Kingston et al., 2022)

Dora^A has decreased cell size | somatic clone phenotype, suppressible by dia^UASp.EGFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has decreased cell size | somatic clone phenotype, suppressible by Scer\GAL4^unspecified/SCAR^GD11380

(Molina-Pelayo et al., 2022)

Dora^A has decreased cell size | somatic clone phenotype, suppressible by Act5C^UASp.GFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dora^A has wing | somatic clone | P-stage phenotype, suppressible by Act5C^UASp.GFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has hemocyte | somatic clone phenotype, suppressible by dia^UASp.EGFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has hemocyte | somatic clone phenotype, suppressible by Scer\GAL4^unspecified/SCAR^GD11380

(Molina-Pelayo et al., 2022)

Dora^A has hemocyte | somatic clone phenotype, suppressible by Act5C^UASp.GFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has actin cytoskeleton | somatic clone | P-stage phenotype, suppressible by dia^UASp.EGFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has wing | somatic clone | P-stage phenotype, suppressible by dia^UASp.EGFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Dora^A has actin cytoskeleton | somatic clone | P-stage phenotype, suppressible by Act5C^UASp.GFP/Scer\GAL4^unspecified

(Molina-Pelayo et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dora^A is rescued by Scer\GAL4^unspecified/Dora^{WT.UAS.Tag:HA}

(Molina-Pelayo et al., 2022)

Not rescued by

Dora^A is not rescued by Scer\GAL4^unspecified/Dora^{ΔC.UAS.Tag:HA}

(Molina-Pelayo et al., 2022)

Comments

Rescued by: Dp(1;3)DC353.

(Yamamoto et al., 2013-)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

52333

y¹ w^* Dora^A P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG34401^A

(Yamamoto et al., 2013-)

Dora^A

(Sheng et al., 2023)

dora^A

(Kingston et al., 2022)

pldo^A

(Wu et al., 2024, Molina-Pelayo et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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