FB2025_01 , released February 20, 2025
Allele: Dmel\PsnRNAi.UAS.cUa
Open Close
General Information
Symbol
Dmel\PsnRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0299126
Feature type
allele
Associated gene
Dmel\Psn
Associated Insertion(s)
Carried in Construct
P{UAS-Psn.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(Li et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Li et al., 2011)
Mutagen
in vitro construct
(Li et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Psn.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of a Psn RNAi line.

(Li et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Psn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  dilated cardiomyopathy
      CEA
      (Li et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PsndsRNA.Scer\UAS.cUa under the control of Scer\GAL4how-24B leads to a significantly reduced heart rate and age-dependent increase in end-diastolic vertical dimensions. Flies exhibit irregular heartbeat rhythms accompanied by cardiomyofibril defects and mitochondrial impairment.

      Expression of PsndsRNA.Scer\UAS.cUa driven by Scer\GAL4ptc-559.1 leads to loss of the anterior crossvein, with normal intervein cells between the L3 and L4 vein.

      (Li et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PsnRNAi.UAS.cUa
      PsndsRNA.Scer\UAS.cUa
      PsndsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)