FB2025_01 , released February 20, 2025
Allele: Dmel\Fmr1KK107935
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General Information
Symbol
Dmel\Fmr1KK107935
Species
D. melanogaster
Name
FlyBase ID
FBal0301533
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
Carried in Construct
P{KK107935}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Meadows, 2014.12.12)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Meadows, 2014.12.12)
Mutagen
in vitro construct
(Meadows, 2014.12.12)
Progenitor genotype
Carried in construct
P{KK107935}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Meadows, 2014.12.12)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK107935
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  fragile X syndrome
      CEA with Fmr1Δ113M
      (Luhur et al., 2017)
      CEA
      (Mansilla et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Fmr1KK107935 leads to a significant decrease in smell perception, in both attraction (expression driven by Scer\GAL4GH146 or Scer\GAL4Sxl-NP2426) and aversion (expression driven by Scer\GAL4GH146) olfactory assays, as compared to controls.

      (Franco et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fmr1KK107935
      Name Synonyms
      Secondary FlyBase IDs
        References (9)