FB2025_01 , released February 20, 2025
Allele: Dmel\SarmΔSAM.ΔTIR.UAS.EGFP
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General Information
Symbol
Dmel\SarmΔSAM.ΔTIR.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0327556
Feature type
allele
Associated gene
Dmel\Sarm
Associated Insertion(s)
Carried in Construct
P{UAS-Sarm.ΔSAM.ΔTIR.eGFP}
Key Links
Transgenic product class
inframe_deletion
(Neukomm et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Neukomm et al., 2017)
Mutagen
in vitro construct
(Neukomm et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Sarm.ΔSAM.ΔTIR.eGFP}
Cytology
Description

UAS regulatory sequences drive expression of Ect4 with deletion of the SAM (aa931-1072) and TIR (aa1091-1228) domains. Tagged with EGFP.

(Neukomm et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sarm
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4VGlut1-OK371/SarmΔSAM.ΔTIR.UAS.EGFP fails to rescue Sarm896

      (Neukomm et al., 2017)
      Comments

      The axon death defect (severed sensory neuron axons in the adult wing persist after an axotomy, instead of being cleared away) observed in flies carrying Ect4896 neuronal mutant clones cannot be rescued by Scer\GAL4VGlut-OK371-driven expression of Ect4ΔSAM.ΔTIR.Scer\UAS.T:Avic\GFP-EGFP in the mutant clones.

      (Neukomm et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ect4ΔSAM.ΔTIR.Scer\UAS.T:Avic\GFP-EGFP
      Ect4ΔSAM.ΔTIR.UAS.EGFP
      SarmΔSAM.ΔTIR.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)