FB2025_01 , released February 20, 2025
Allele: Dmel\CG5445UAS.cUa
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General Information
Symbol
Dmel\CG5445UAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Uechi
FlyBase ID
FBal0337939
Feature type
allele
Associated gene
Dmel\CG5445
Associated Insertion(s)
Carried in Construct
P{UAS-CG5445.U}
Key Links
Transgenic product class
wild_type
(Uechi et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Uechi et al., 2018)
Mutagen
in vitro construct
(Uechi et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-CG5445.U}
Cytology
Description

UAS regulatory sequences drive expression of full-length CG5445.

(Uechi et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CG5445
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\TARDBPUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor | partially of abnormal eye color | progressive phenotype of Hsap\TARDBPUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4RapGAP1-OK6 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Hsap\FUSR521C.UAS.Tag:HA, Scer\GAL4RapGAP1-OK6

      (Uechi et al., 2018)

      CG5445UAS.cUa/Scer\GAL4GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\TARDBPM337V.UAS.Tag:MYC

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor of visible | adult stage | progressive phenotype of Hsap\TARDBPM337V.UAS.Tag:MYC, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor of visible | adult stage | progressive phenotype of Hsap\FUSR521C.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\FUSR521C.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor of visible | adult stage | progressive phenotype of Hsap\FUSUAS.Tag:HA, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\FUSUAS.Tag:HA, Scer\GAL4GMR.PU

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4pnr-MD237 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4pnr-MD237, TxlNIG.5495R

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4RapGAP1-OK6 is a suppressor | partially of some die during pupal stage phenotype of Hsap\TARDBPM337V.UAS.Tag:MYC, Scer\GAL4RapGAP1-OK6

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4RapGAP1-OK6 is a suppressor | partially of visible | adult stage phenotype of Hsap\TARDBPM337V.UAS.Tag:MYC, Scer\GAL4RapGAP1-OK6

      (Uechi et al., 2018)

      CG5445UAS.cUa, Scer\GAL4RapGAP1-OK6 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Hsap\TARDBPM337V.UAS.Tag:MYC, Scer\GAL4RapGAP1-OK6

      (Uechi et al., 2018)
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal dark pigmentation in the central thorax of adult flies expressing TxlNIG.5495R under the control of Scer\GAL4pnr-MD237 is ameliorated co-expression of CG5445Scer\UAS.cUa.

      (Uechi et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference

      The age-dependent eye degeneration and loss of pigmentation observed in flies expressing any of the following: Hsap\TARDBPM337V.Scer\UAS.T:Hsap\MYC, Hsap\TARDBPScer\UAS.T:Hsap\MYC, Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 or Hsap\FUSScer\UAS.T:Ivir\HA1 (but not the eye defects induced by expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1) under the control of Scer\GAL4GMR.PU is significantly ameliorated by co-expression of CG5445Scer\UAS.cUa.

      Similarly, the partial pupal lethality of animals expressing Hsap\TARDBPM337V.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4RapGAP1-OK6 is strongly mitigated by co-expression of CG5445Scer\UAS.cUa; the wing expansion and climbing defects observed in the Hsap\TARDBPM337V.Scer\UAS.T:Hsap\MYC-expressing flies that manage to eclose are also partially suppressed as flies that expand their wings normally are recovered and the percentage of adults that can climb is increased.

      The wing expansion defects observed in flies expressing Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 with the Scer\GAL4RapGAP1-OK6 driver are not rescued by co-expression of CG5445Scer\UAS.cUa, whereas their poor climbing ability is significantly improved.

      (Uechi et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG5445Scer\UAS.cUa
      CG5445UAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Uechi
      Secondary FlyBase IDs
        References (1)