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General Information
Symbol
Dmel\Nup62TRiP.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0340160
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a Nup62 RNAi construct.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of Nup62TRiP.cUa under the control of Scer\GAL4unspecified leads to excessive chromatin positioning in the nuclear periphery in nurse cells and an increased nuclear diameter in oocytes, but it does not disrupt overall structural integrity of the nuclear pore complex or the active import function.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The karyosome disruption - aberrant attachment of the chromatin to nuclear periphery - characteristic for oocytes expressing Nup62TRiP.cUa under the control of Scer\GAL4unspecified is significantly improved by co-expression of Nup154HMS01189 and further worsened by co-expression of CG14215dsRNA.UAS, while co-expression of either Nup50HMS01054 or Nup160HMS00385 do not significantly alter the phenotype. The excessive chromatin positioning in the nuclear periphery in nurse cells of Nup62TRiP.cUa-expressing females is also rescued by co-expression of Nup154HMS01189. The increased nuclear diameter observed in oocytes expressing Nup62TRiP.cUa under the control of Scer\GAL4unspecified is not reduced by co-expression of Nup154HMS01189 (which on its own actually also increases the nuclear size).
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Nup62TRiP.cUa
Name Synonyms
Secondary FlyBase IDs
    References (1)