FB2025_01 , released February 20, 2025
Allele: Dmel\Idh3a3
Open Close
General Information
Symbol
Dmel\Idh3a3
Species
D. melanogaster
Name
FlyBase ID
FBal0341826
Feature type
allele
Associated gene
Dmel\Idh3a
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ugur et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y198term.

(Ugur et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,519,969..19,519,969 [-]
Nucleotide change:

C19519969G

Amino acid change:

Y175term | Idh3a-PA; Y175term | Idh3a-PC; Y198term | Idh3a-PD

Reported amino acid change:

Y198term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Ugur et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  chromosome 15q11.2 deletion syndrome
      modeled by Cyfip85.1
      (Kanellopoulos et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The neuromuscular junction in Idh3a3 hemizygous larvae display increased frequency of miniature excitatory junction potentials, increased miniature excitatory junction current frequency and amplitude and decreased quantal content.

      Idh3a3 eye-specific clones (ey-FLP) show defective retinal synaptic transmission, with loss of on and off transients.

      (Ugur et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Idh3a3 has retina | somatic clone - tissue specific phenotype, suppressible by Dp(1;3)DC362

      (Ugur et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Idh3a3
      (Kanellopoulos et al., 2020)
      idh3a3
      (Ugur et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)