FlyBase Allele Report: Hsap\PLA2G6[S519A.UAS]

General Information

Symbol

Hsap\PLA2G6^S519A.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0343303

Feature type

allele

Associated gene

Hsap\PLA2G6

Associated Insertion(s)

Carried in Construct

PBac{UAS-hPLA2G6.S519A}

Key Links

Transgenic product class

missense_variant

(Lin et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Lin et al., 2018)

Mutagen

in vitro construct

(Lin et al., 2018)

Progenitor genotype

Carried in construct

PBac{UAS-hPLA2G6.S519A}

Cytology

Description

UASt regulatory sequences drive expression of a catalytically impaired form of Hsap\PLA2G6 (cDNA sequence derived from the MGC:45156 clone, mutated to carry the S519A amino acid replacement).

(Lin et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PLA2G6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 14

modeled by iPLA2-VIA^Δ174

(Lin et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor of short lived phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor | partially of bang sensitive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor of abnormal neurophysiology | adult stage | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor of decreased cell number | adult stage | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor of retina | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Hsap\PLA2G6^S519A.UAS/Scer\GAL4^Act5C.PI is a suppressor of eye photoreceptor cell | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80138

y¹ w^*; PBac{UAS-hPLA2G6.S519A}VK00037/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\PLA2G6^S519A.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close