FB2025_01 , released February 20, 2025
Allele: Dmel\MarfKO.mCherry
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General Information
Symbol
Dmel\MarfKO.mCherry
Species
D. melanogaster
Name
amorphic allele - molecular evidence
FlyBase ID
FBal0344034
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
TI{TI}MarfKO.mCherry
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(El Fissi et al., 2018)
Progenitor genotype
Associated Insertion(s)
TI{TI}MarfKO.mCherry
Cytology
Description

Replacement of Marf (10-bp upstream of the ATG and up to the stop codon) with a mCherry and w+* marker.

(El Fissi et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Charcot-Marie-Tooth disease type 2
      CEA
      (El Fissi et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MarfKO.mCherry homozygous larval motor neuron cell bodies present fragmented mitochondria, as compared to controls.

      (El Fissi et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      MarfKO.mCherry is partially rescued by MarfWT.UAS/Scer\GAL4VGlut1-OK371

      (El Fissi et al., 2018)

      MarfKO.mCherry is partially rescued by Scer\GAL4VGlut1-OK371/MarfR94Qlike.UAS

      (El Fissi et al., 2018)

      MarfKO.mCherry is partially rescued by Scer\GAL4VGlut1-OK371/MarfT105Mlike.UAS

      (El Fissi et al., 2018)

      MarfKO.mCherry is partially rescued by Scer\GAL4VGlut1-OK371/MarfR364Wlike.UAS

      (El Fissi et al., 2018)

      MarfKO.mCherry is partially rescued by Scer\GAL4VGlut1-OK371/MarfL76Plike.UAS

      (El Fissi et al., 2018)
      Comments

      Fails to rescue: Marf[R94Qlike.UAS]

      Fails to rescue: Marf[T105Mlike.UAS]

      Fails to rescue: Marf[R364Wlike.UAS]

      Fails to rescue: Marf[L76Plike.UAS]

      (El Fissi et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MarfKO.mCherry
      marfKO
      (El Fissi et al., 2018)
      Name Synonyms
      amorphic allele - molecular evidence
      Secondary FlyBase IDs
        References (1)