FB2025_01 , released February 20, 2025
Allele: Dmel\MitofilinUAS.cYa
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General Information
Symbol
Dmel\MitofilinUAS.cYa
Species
D. melanogaster
Name
UAS construct a of Yoon
FlyBase ID
FBal0351590
Feature type
allele
Associated gene
Dmel\Mitofilin
Associated Insertion(s)
Carried in Construct
P{UAS-Mitofilin.Y}
Key Links
Transgenic product class
wild_type
(Yoon et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yoon et al., 2019)
Mutagen
in vitro construct
(Yoon et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-Mitofilin.Y}
Cytology
Description

UASt regulates expression of Mitofilin.

(Yoon et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mitofilin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing MitofilinUAS.cYa under the control of Scer\GAL4Mhc.PU display deformed mitochondria in thoracic muscles, reduced locomotor activity and slower walking speed than controls.

      (Yoon et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adult flies co-expressing Adck1UAS.cYa and MitofilinUAS.cYa under the control of Scer\GAL4Mhc.PU display unusual elongated and continuous mitochondria in thoracic muscles.

      (Yoon et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MitofilinUAS.cYa
      Name Synonyms
      UAS construct a of Yoon
      Secondary FlyBase IDs
        References (1)