FlyBase Allele Report: Dmel\hyx[HT622]

General Information

Symbol

Dmel\hyx^HT622

Species

D. melanogaster

Name

FlyBase ID

FBal0385616

Feature type

allele

Associated gene

Dmel\hyx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Deng et al., 2022)

Mutagen

ethyl methanesulfonate

(Deng et al., 2022)

Progenitor genotype

Cytology

Description

74bp deletion (nucleotides 728-801) results in a frameshift mutation and generation of a stop codon at amino acid 248 in endogenous hyx.

(Deng et al., 2022)

Amino acid replacement: ?248term.

(Deng et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:9,040,764..9,040,837 [+]

Comment:

A 74bp deletion in hyx starting in amino acid 243 that causes a frameshift and leads to early translation termination after the addition of 5 novel amino acids (SAQSH).

(Deng et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hyx^HT622 has increased cell number | somatic clone | larval stage phenotype, suppressible by Hsap\CDC73^UAS.cMa/Scer\GAL4^wor.PA

(Deng et al., 2022)

hyx^HT622 has increased cell number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\CDC73^UAS.cMa

(Deng et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

hyx^HT622 has larval neuroblast | increased number | somatic clone phenotype, suppressible by Hsap\CDC73^UAS.cMa/Scer\GAL4^wor.PA

(Deng et al., 2022)

hyx^HT622 has larval neuroblast | increased number | somatic clone phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\CDC73^UAS.cMa

(Deng et al., 2022)

hyx^HT622 has type I neuroblast | increased number | somatic clone | larval stage phenotype, suppressible by Hsap\CDC73^UAS.cMa/Scer\GAL4^wor.PA

(Deng et al., 2022)

hyx^HT622 has type II neuroblast | increased number | somatic clone | larval stage phenotype, suppressible by Hsap\CDC73^UAS.cMa/Scer\GAL4^wor.PA

(Deng et al., 2022)

hyx^HT622 has type I neuroblast | increased number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\CDC73^UAS.cMa

(Deng et al., 2022)

hyx^HT622 has type II neuroblast | increased number | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\CDC73^UAS.cMa

(Deng et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hyx^HT622 is rescued by hyx^UAS.cMa/Scer\GAL4^insc-Mz1407

(Deng et al., 2022)

hyx^HT622 is rescued by hyx^UAS.cMa/Scer\GAL4^wor.PA

(Deng et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hyx^HT622

(Deng et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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