FB2025_01 , released February 20, 2025
Pathway: GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
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General Information
Name
GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
Species
D. melanogaster
Symbol
MANGPG
FlyBase ID
FBgg0002055
Date last reviewed
2024-11-20
Number of members
7
Description
Description
The nucleotide-sugar GDP-D-mannose is primarily synthesized in the cytosol from D-glucose (though it can also be produced from D-mannose). GDP-D-mannose is a precursor for GDP-L-fucose biosynthesis and protein glycosylation. (Adapted from PMID:24931670.)
Notes

Hex-t1 and Hex-t2 are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hex-t1 is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-t1 and Hex-t2 are not included in the gene list.

Source Material
The GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE Gene Group has been compiled using the following publication(s): Parkinson et al., 2016 .
Key Gene Ontology (GO) terms
Biological Process
GDP-D-mannose biosynthetic process from fructose-6-phosphate
Cellular Component
cytosol
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gmppa
GDP-mannose pyrophosphorylase A
(FlyBase, 2024-)
Gmppb
GDP-mannose pyrophosphorylase B
(FlyBase, 2024-)
Hex-A
Hexokinase A
HexA, HEX, hexokinase, HK, HK-A
(FlyBase, 2024-)
Hex-C
Hexokinase C
HEX, HexC, hexokinase, HK, HK-C
(FlyBase, 2024-)
Mpi
Mannose phosphate isomerase
(Parkinson et al., 2016)
Pgi
Phosphoglucose isomerase
Gpi, glucose phosphate isomerase
(FlyBase, 2024-)
Pmm2
Phosphomannomutase type 2
(Parkinson et al., 2016)
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: GDP-mannose biosynthesis](https://biocyc.org/pathway?orgid=FLY&id=PWY-5659)

[Reactome: Synthesis of GDP-mannose](https://reactome.org/PathwayBrowser/#/R-DME-446205)

[KEGG: Fructose and mannose metabolism](https://www.genome.jp/pathway/dme00051)

Synonyms and Secondary IDs
Synonym(s)
MANGPG
GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
Secondary FlyBase ID(s)
References (3)