Reference Report

Reference
Citation	Howard, K.R., Struhl, G. (1990). Decoding positional information: regulation of the pair-rule gene hairy. Development 110(): 1223--1231. (Export to RIS)
FlyBase ID	FBrf0051551
Publication Type	Research paper
PubMed ID	2100260
PubMed Abstract	In the series of local gene activations that occur during early Drosophila development, the striped expression patterns of the pair-rule genes provide the first indication of segmental periodicity. The experiments that we report here address the question of how these patterns arise, by studying the regulation of one of these genes, hairy. We show that each of the seven stripes of hairy expression is controlled by a distinct subset of cis-acting regulatory elements, some mediating transcriptional activation and others transcriptional repression. In general, elements necessary and sufficient for triggering a particular stripe response are clustered on the DNA and appear to overlap or be interspersed with elements involved in at least one other stripe response. Our results extend previous findings suggesting that periodic hairy expression arises by a decoding process in which each stripe is triggered by particular combinations or concentrations of regulatory factors. These regulatory factors are likely to include the products of the gap class of segmentation genes that are required for activating or positioning particular subsets of hairy stripes and are expressed with overlapping distributions during early embryogenesis.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (26)
	Ecol\lacZ^h.ET1 Ecol\lacZ^h.ET2 Ecol\lacZ^h.ET5 Ecol\lacZ^h.ET6 Ecol\lacZ^h.ET7 Ecol\lacZ^h.ET8 Ecol\lacZ^h.ET10 Ecol\lacZ^h.ET12 Ecol\lacZ^h.ET13 Ecol\lacZ^h.ET15 Ecol\lacZ^h.ET16 Ecol\lacZ^h.ET17 Ecol\lacZ^h.ET21 Ecol\lacZ^h.ET22 Ecol\lacZ^h.ET29- Ecol\lacZ^h.ET30 Ecol\lacZ^h.ET31 Ecol\lacZ^h.ET38 Ecol\lacZ^h.ET44 Ecol\lacZ^h.ET51 Ecol\lacZ^Hsp70Bb.HZ50 h⁴² h⁴⁹ h⁵⁰ h⁵¹ h^tHa
Constructs (20)
	P{ET1} P{ET2} P{ET5} P{ET6} P{ET7} P{ET8} P{ET10} P{ET12} P{ET13} P{ET15} P{ET16} P{ET17} P{ET21} P{ET22} P{ET29-} P{ET30} P{ET31} P{ET38} P{ET44} P{ET51}
Genes (2)
	Ecol\lacZ h
Sequence features (12)
	h_ET31 h_rescue_5 h_stripe3_ET38 h_stripe_3+4_ET22 h_stripe_6+2 h-reg_element-1 h-reg_element-2 h-reg_element-3 h-reg_element-5 h-reg_element-6 h-reg_element-7 h-reg_element-9