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Reference Report
| Reference | |||
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| Citation | Lee, J.H., Lee, E., Park, J., Kim, E., Kim, J., Chung, J. (2003). In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett. 550(1-3): 5--10. (Export to RIS) | ||
| FlyBase ID | FBrf0162129 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12935877 | ||
| PubMed Abstract | p53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation-induced apoptosis and reaper induction. These results indicate that Dmp53 is a central component of DNA damage-dependent apoptotic signaling. | ||
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | FEBS Lett. | ||
| Title | FEBS Letters | ||
| Publication Year | 1968- | ||
| ISBN/ISSN | 0014-5793 | ||
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Data from Reference
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| Alleles (6)
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| Constructs (2)
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| Genes (7)
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| Insertions (2)
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