FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term antibody-dependent cellular cytotoxicity ID (Ontology) GO:0001788 (Gene Ontology)
Definition Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.[ ISBN:0781735149 PubMed:11677095 PubMed:9581795 ]
Also Known As "ADCC" ; "antibody dependent cell death" ; "antibody dependent cell killing" (for all, see Synonyms field below)
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cell killing
 |__leukocyte mediated cytotoxicity__
leukocyte mediated immunity          |
 |__leukocyte mediated cytotoxicity__|
type II hypersensitivity             |
 |__type IIa hypersensitivity________|
                                     antibody-dependent cellular cytotoxicity
                                      |__regulation of antibody-dependent cellular cytotoxicity
                                          |__negative regulation of antibody-dependent cellular cytotoxicity
                                          |__positive regulation of antibody-dependent cellular cytotoxicity
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Is a type IIa hypersensitivity
leukocyte mediated cytotoxicity
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Synonyms
  • "ADCC" EXACT
    "antibody dependent cell death" EXACT
    "antibody dependent cell killing" EXACT
    "antibody-dependent cell death" EXACT
    "antibody-dependent cell killing" EXACT
    "type VI hypersensitivity" EXACT
Secondary IDs
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Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
Wikipedia:Antibody-dependent_cellular_cytotoxicity