FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term T cell mediated cytotoxicity ID (Ontology) GO:0001913 (Gene Ontology)
Definition The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.[ ISBN:0781735149 PubMed:11911826 ]
Also Known As "T cell mediated apoptosis" ; "T cell mediated cell death" ; "T cell mediated cell killing" (for all, see Synonyms field below)
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cell killing
 |__leukocyte mediated cytotoxicity________________________________________________________________________________________
leukocyte mediated immunity                                                                                         |
 |__leukocyte mediated cytotoxicity________________________________________________________________________________________|
lymphocyte mediated immunity                                                                                         |
 |__T cell mediated immunity_________________________________________________________________________________________|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  |
 |__T cell mediated immunity_________________________________________________________________________________________|
                                                                                         T cell mediated cytotoxicity
                                                                                          |__cytotoxic T cell degranulation
                                                                                          |   |__regulation of cytotoxic T cell degranulation(+)
                                                                                          |__regulation of T cell mediated cytotoxicity
                                                                                          |   |__negative regulation of T cell mediated cytotoxicity(+)
                                                                                          |   |__positive regulation of T cell mediated cytotoxicity(+)
                                                                                          |   |__regulation of cytotoxic T cell degranulation(+)
                                                                                          |   |__regulation of T cell mediated cytotoxicity directed against tumor cell target(+)
                                                                                          |__T cell mediated cytotoxicity directed against tumor cell target
                                                                                              |__regulation of T cell mediated cytotoxicity directed against tumor cell target(+)
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Is a leukocyte mediated cytotoxicity
T cell mediated immunity
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Synonyms
  • "T cell mediated apoptosis" EXACT
    "T cell mediated cell death" EXACT
    "T cell mediated cell killing" EXACT
    "T cell mediated cytolysis" RELATED
    "T lymphocyte mediated cytotoxicity" EXACT
    "T-cell mediated apoptosis" EXACT
    "T-cell mediated cell death" EXACT
    "T-cell mediated cell killing" EXACT
    "T-cell mediated cytotoxicity" EXACT
    "T-lymphocyte mediated cytotoxicity" EXACT
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