FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term complement activation, classical pathway ID (Ontology) GO:0006958 (Gene Ontology)
Definition Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.[ ISBN:0781735149 ]
Also Known As "complement cascade, classical pathway"
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immune effector process
 |__complement activation___________________________________________
activation of immune response                                       |
 |__complement activation___________________________________________|
humoral immune response                                             |
 |__humoral immune response mediated by circulating immunoglobulin__|
 |__complement activation___________________________________________|
immunoglobulin mediated immune response                             |
 |__humoral immune response mediated by circulating immunoglobulin__|
                                                                    complement activation, classical pathway
                                                                     |__regulation of complement activation, classical pathway
                                                                         |__negative regulation of complement activation, classical pathway
                                                                         |__positive regulation of complement activation, classical pathway
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Is a complement activation
Part of humoral immune response mediated by circulating immunoglobulin
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Synonyms
  • "complement cascade, classical pathway" EXACT
Secondary IDs
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Reactome:R-HSA-173623 "Classical antibody-mediated complement activation"