FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term G protein-coupled receptor signaling pathway ID (Ontology) GO:0007186 (Gene Ontology)
Definition The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.[ PubMed:16902576 PubMed:24568158 ]
Also Known As "G protein coupled receptor protein signaling pathway" ; "G protein coupled receptor protein signalling pathway" ; "G-protein coupled receptor protein signal transduction" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     158
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)      20    158
     involved_in | G protein-coupled receptor signaling pathway       --     158
Spanning Tree (Parents/Children)
Only view relationship: 
cell communication______________
cellular process________________|
signaling_______________________|
regulation of cellular process__|
cellular response to stimulus___|
                                signal transduction
                                 |__G protein-coupled receptor signaling pathway  273 rec.
                                     |__adenylate cyclase-modulating G protein-coupled receptor signaling pathway 65 rec.
                                     |   |__adenylate cyclase-activating G protein-coupled receptor signaling pathway(+) 44 rec.
                                     |   |__adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway(+) 12 rec.
                                     |__adrenergic receptor signaling pathway 8 rec.
                                     |   |__adenylate cyclase-activating adrenergic receptor signaling pathway(+) 8 rec.
                                     |   |__adenylate cyclase-inhibiting adrenergic receptor signaling pathway(+)
                                     |   |__MAPK-activating adrenergic receptor signaling pathway
                                     |   |__phospholipase C-activating adrenergic receptor signaling pathway
                                     |__angiotensin-activated signaling pathway 1 rec.
                                     |   |__angiotensin-activated signaling pathway involved in heart process(+)
                                     |   |__phospholipase C-activating angiotensin-activated signaling pathway(+)
                                     |   |__regulation of angiotensin-activated signaling pathway(+)
                                     |__apelin receptor signaling pathway
                                     |__bombesin receptor signaling pathway
                                     |__calcitonin family receptor signaling pathway
                                     |   |__adrenomedullin receptor signaling pathway
                                     |   |__amylin receptor signaling pathway(+)
                                     |   |__calcitonin gene-related peptide receptor signaling pathway
                                     |__cannabinoid signaling pathway
                                     |   |__endocannabinoid signaling pathway(+)
                                     |__chemokine-mediated signaling pathway
                                     |   |__C-C chemokine receptor CCR2 signaling pathway(+)
                                     |   |__C-C chemokine receptor CCR4 signaling pathway(+)
                                     |   |__C-C chemokine receptor CCR7 signaling pathway(+)
                                     |   |__C-X-C chemokine receptor CXCR4 signaling pathway(+)
                                     |   |__chemokine (C-C motif) ligand 2 signaling pathway(+)
                                     |   |__chemokine (C-C motif) ligand 5 signaling pathway
                                     |   |__chemokine (C-C motif) ligand 19 signaling pathway(+)
                                     |   |__chemokine (C-C motif) ligand 21 signaling pathway(+)
                                     |   |__chemokine (C-X-C motif) ligand 12 signaling pathway(+)
                                     |   |__regulation of chemokine-mediated signaling pathway(+)
                                     |   |__thrombopoietin-mediated signaling pathway
                                     |__cholecystokinin signaling pathway
                                     |   |__positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway
                                     |__complement component C5a signaling pathway
                                     |__endothelin receptor signaling pathway
                                     |   |__endothelin receptor signaling pathway involved in heart process
                                     |   |__phospholipase C-activating endothelin receptor signaling pathway
                                     |__follicle-stimulating hormone signaling pathway
                                     |__G protein-coupled acetylcholine receptor signaling pathway 4 rec.
                                     |   |__adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 2 rec.
                                     |   |__G protein-coupled acetylcholine receptor signaling pathway involved in heart process(+)
                                     |   |__G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission
                                     |   |__phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
                                     |__G protein-coupled chemorepellent receptor signaling pathway
                                     |__G protein-coupled dopamine receptor signaling pathway 9 rec.
                                     |   |__adenylate cyclase-activating dopamine receptor signaling pathway 4 rec.
                                     |   |__adenylate cyclase-inhibiting dopamine receptor signaling pathway(+)
                                     |   |__phospholipase C-activating dopamine receptor signaling pathway
                                     |   |__regulation of dopamine receptor signaling pathway(+) 1 rec.
                                     |__G protein-coupled glutamate receptor signaling pathway 3 rec.
                                     |   |__adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
                                     |   |__phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
                                     |__G protein-coupled opioid receptor signaling pathway
                                     |   |__adenylate cyclase-inhibiting opioid receptor signaling pathway(+)
                                     |   |__regulation of opioid receptor signaling pathway(+)
                                     |__G protein-coupled opsin signaling pathway 23 rec.
                                     |   |__phospholipase C-activating opsin-mediated signaling pathway 6 rec.
                                     |   |__regulation of opsin-mediated signaling pathway(+) 15 rec.
                                     |   |__transducin-mediated opsin signaling pathway
                                     |__G protein-coupled purinergic receptor signaling pathway 2 rec.
                                     |   |__G protein-coupled adenosine receptor signaling pathway(+) 1 rec.
                                     |__G protein-coupled receptor signaling pathway involved in dauer larval development
                                     |__G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium
                                     |__G protein-coupled receptor signaling pathway involved in heart process
                                     |   |__adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process(+)
                                     |   |__angiotensin-activated signaling pathway involved in heart process(+)
                                     |   |__endothelin receptor signaling pathway involved in heart process
                                     |   |__G protein-coupled acetylcholine receptor signaling pathway involved in heart process(+)
                                     |__G protein-coupled receptor signaling pathway involved in social behavior 1 rec.
                                     |__G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 9 rec.
                                     |   |__G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
                                     |__G protein-coupled serotonin receptor signaling pathway 2 rec.
                                     |   |__adenylate cyclase-inhibiting serotonin receptor signaling pathway 2 rec.
                                     |   |__phospholipase C-activating serotonin receptor signaling pathway 2 rec.
                                     |__gastric inhibitory peptide signaling pathway
                                     |__leukotriene signaling pathway
                                     |__luteinizing hormone signaling pathway
                                     |   |__luteinizing hormone signaling pathway involved in ovarian follicle development
                                     |__neuropeptide signaling pathway 59 rec.
                                     |   |__galanin-activated signaling pathway
                                     |__octopamine or tyramine signaling pathway 10 rec.
                                     |   |__octopamine signaling pathway(+) 6 rec.
                                     |   |__regulation of octopamine or tyramine signaling pathway(+) 4 rec.
                                     |   |__tyramine signaling pathway(+) 3 rec.
                                     |__phospholipase C-activating G protein-coupled receptor signaling pathway 26 rec.
                                     |   |__phospholipase C-activating adrenergic receptor signaling pathway
                                     |   |__phospholipase C-activating angiotensin-activated signaling pathway(+)
                                     |   |__phospholipase C-activating dopamine receptor signaling pathway
                                     |   |__phospholipase C-activating endothelin receptor signaling pathway
                                     |   |__phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
                                     |   |__phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
                                     |   |__phospholipase C-activating N-formyl peptide-activated signaling pathway
                                     |   |__phospholipase C-activating opsin-mediated signaling pathway 6 rec.
                                     |   |__phospholipase C-activating serotonin receptor signaling pathway 2 rec.
                                     |   |__phospholipase C-activating tachykinin receptor signaling pathway
                                     |   |__regulation of phospholipase C-activating G protein-coupled receptor signaling pathway(+) 7 rec.
                                     |__phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1 rec.
                                     |__phospholipase D-activating G protein-coupled receptor signaling pathway
                                     |__regulation of G protein-coupled receptor signaling pathway 36 rec.
                                     |   |__cross-receptor inhibition within G protein-coupled receptor heterodimer
                                     |   |__negative regulation of G protein-coupled receptor signaling pathway(+) 20 rec.
                                     |   |__positive regulation of G protein-coupled receptor signaling pathway(+) 8 rec.
                                     |   |__protein kinase C deactivation
                                     |   |__regulation of adenosine receptor signaling pathway(+)
                                     |   |__regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway(+) 2 rec.
                                     |   |__regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway
                                     |   |__regulation of angiotensin-activated signaling pathway(+)
                                     |   |__regulation of chemokine-mediated signaling pathway(+)
                                     |   |__regulation of dopamine receptor signaling pathway(+) 1 rec.
                                     |   |__regulation of endocannabinoid signaling pathway
                                     |   |__regulation of G protein-coupled receptor internalization(+)
                                     |   |__regulation of octopamine or tyramine signaling pathway(+) 4 rec.
                                     |   |__regulation of opioid receptor signaling pathway(+)
                                     |   |__regulation of opsin-mediated signaling pathway(+) 15 rec.
                                     |   |__regulation of phospholipase C-activating G protein-coupled receptor signaling pathway(+) 7 rec.
                                     |   |__regulation of thrombin-activated receptor signaling pathway(+)
                                     |__Rho-activating G protein-coupled receptor signaling pathway
                                     |__somatostatin receptor signaling pathway
                                     |   |__somatostatin signaling pathway
                                     |__sphingosine-1-phosphate receptor signaling pathway
                                     |__tachykinin receptor signaling pathway 4 rec.
                                     |   |__phospholipase C-activating tachykinin receptor signaling pathway
                                     |__thrombin-activated receptor signaling pathway
                                     |   |__regulation of thrombin-activated receptor signaling pathway(+)
                                     |__thromboxane A2 signaling pathway
                                     |__thyroid-stimulating hormone signaling pathway
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Synonyms
  • "dimeric G-protein coupled receptor signaling pathway" NARROW
    "dimeric G-protein coupled receptor signalling pathway" NARROW
    "G protein coupled receptor protein signaling pathway" EXACT
    "G protein coupled receptor protein signalling pathway" EXACT
    "G-protein coupled receptor protein signal transduction" EXACT
    "G-protein coupled receptor protein signaling pathway" EXACT
    "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW
    "G-protein coupled receptor signalling pathway" EXACT
    "G-protein-coupled receptor protein signalling pathway" EXACT
    "GPCR signaling pathway" EXACT
    "GPCR signalling pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-373076 "Class A/1 (Rhodopsin-like receptors)"
Reactome:R-HSA-388396 "GPCR downstream signalling"